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Page 1
A kinase-cGAS cascade to synthesize a therapeutic STING activator.
McIntosh JA, Liu Z, Andresen BM, Marzijarani NS, Moore JC, Marshall NM, Borra-Garske M, Obligacion JV, Fier PS, Peng F, Forstater JH, Winston MS, An C, Chang W, Lim J, Huffman MA, Miller SP, Tsay FR, Altman MD, Lesburg CA, Steinhuebel D, Trotter BW, Cumming JN, Northrup A, Bu X, Mann BF, Biba M, Hiraga K, Murphy GS, Kolev JN, Makarewicz A, Pan W, Farasat I, Bade RS, Stone K, Duan D, Alvizo O, Adpressa D, Guetschow E, Hoyt E, Regalado EL, Castro S, Rivera N, Smith JP, Wang F, Crespo A, Verma D, Axnanda S, Dance ZEX, Devine PN, Tschaen D, Canada KA, Bulger PG, Sherry BD, Truppo MD, Ruck RT, Campeau LC, Bennett DJ, Humphrey GR, Campos KR, Maddess ML. McIntosh JA, et al. Among authors: tsay fr. Nature. 2022 Mar;603(7901):439-444. doi: 10.1038/s41586-022-04422-9. Epub 2022 Mar 16. Nature. 2022. PMID: 35296845
Automated ion exchange chromatography screening combined with in silico multifactorial simulation for efficient method development and purification of biopharmaceutical targets.
Losacco GL, Hicks MB, DaSilva JO, Wang H, Potapenko M, Tsay FR, Ahmad IAH, Mangion I, Guillarme D, Regalado EL. Losacco GL, et al. Among authors: tsay fr. Anal Bioanal Chem. 2022 May;414(12):3581-3591. doi: 10.1007/s00216-022-03982-z. Epub 2022 Apr 20. Anal Bioanal Chem. 2022. PMID: 35441858
Synthesis of a Complex and Highly Potent PCSK9 Inhibitor.
Kuethe JT, Lee J, Thaisrivongs D, Yasuda N, Pollack SR, Leone J, DaSilva J, Biba M, Tsay FR, Regalado EL, Qi J, Li H, Poggetto GD, Cohen R. Kuethe JT, et al. Among authors: tsay fr. Org Lett. 2023 Jul 14;25(27):5001-5005. doi: 10.1021/acs.orglett.3c01635. Epub 2023 Jun 29. Org Lett. 2023. PMID: 37382389
Highly Chemoselective Trichloroacetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosuppressant L-733,725.
Song Z, DeMarco A, Zhao M, Corley EG, Thompson AS, McNamara J, Li Y, Rieger D, Sohar P, Mathre DJ, Tschaen DM, Reamer RA, Huntington MF, Ho GJ, Tsay FR, Emerson K, Shuman R, Grabowski EJ, Reider PJ. Song Z, et al. Among authors: tsay fr. J Org Chem. 1999 Mar 19;64(6):1859-1867. doi: 10.1021/jo981805g. J Org Chem. 1999. PMID: 11674275
Stereoselective synthesis of an anti-HIV drug candidate.
Conlon DA, Jensen MS, Palucki M, Yasuda N, Um JM, Yang C, Hartner FW, Tsay FR, Hsiao Y, Pye P, Rivera NR, Hughes DL. Conlon DA, et al. Among authors: tsay fr. Chirality. 2005;17 Suppl:S149-58. doi: 10.1002/chir.20137. Chirality. 2005. PMID: 15806573
Practical synthesis of the new carbapenem antibiotic ertapenem sodium.
Williams JM, Brands KM, Skerlj RT, Jobson RB, Marchesini G, Conrad KM, Pipik B, Savary KA, Tsay FR, Houghton PG, Sidler DR, Dolling UH, DiMichele LM, Novak TJ. Williams JM, et al. Among authors: tsay fr. J Org Chem. 2005 Sep 16;70(19):7479-87. doi: 10.1021/jo0501442. J Org Chem. 2005. PMID: 16149774
13 results