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SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models.
Gray E, Ulrich M, Epp A, Younan P, Sahetya D, Hensley K, Allred S, Huang LY, Hahn J, Gahnberg K, Treuting PM, Trueblood ES, Gosink JJ, Thurman R, Wo S, Spahr K, Haass EJ, Snead K, Miller D, Padilla M, Smith AJ, Frantz C, Schrum JP, Nazarenko N, Gardai SJ. Gray E, et al. Among authors: trueblood es. J Immunother Cancer. 2023 Oct;11(10):e007572. doi: 10.1136/jitc-2023-007572. J Immunother Cancer. 2023. PMID: 37793853 Free PMC article.
Development of Novel Antibody-Camptothecin Conjugates.
Lyski RD, Bou LB, Lau UY, Meyer DW, Cochran JH, Okeley NM, Emmerton KK, Zapata F, Simmons JK, Trueblood ES, Ortiz DJ, Zaval MC, Snead KM, Jin S, Farr LM, Ryan MC, Senter PD, Jeffrey SC. Lyski RD, et al. Among authors: trueblood es. Mol Cancer Ther. 2021 Feb;20(2):329-339. doi: 10.1158/1535-7163.MCT-20-0526. Epub 2020 Dec 3. Mol Cancer Ther. 2021. PMID: 33273058
AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma.
Hamblett KJ, Kozlosky CJ, Siu S, Chang WS, Liu H, Foltz IN, Trueblood ES, Meininger D, Arora T, Twomey B, Vonderfecht SL, Chen Q, Hill JS, Fanslow WC. Hamblett KJ, et al. Among authors: trueblood es. Mol Cancer Ther. 2015 Jul;14(7):1614-24. doi: 10.1158/1535-7163.MCT-14-1078. Epub 2015 Apr 30. Mol Cancer Ther. 2015. PMID: 25931519
IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.
Blumberg H, Dinh H, Dean C Jr, Trueblood ES, Bailey K, Shows D, Bhagavathula N, Aslam MN, Varani J, Towne JE, Sims JE. Blumberg H, et al. Among authors: trueblood es. J Immunol. 2010 Oct 1;185(7):4354-62. doi: 10.4049/jimmunol.1000313. Epub 2010 Sep 10. J Immunol. 2010. PMID: 20833839
12 results