Troutman J - Search Results

1

In vitro to in vivo extrapolation for high throughput prioritization and decision making.

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC. Bell SM, et al. Among authors: troutman j. Toxicol In Vitro. 2018 Mar;47:213-227. doi: 10.1016/j.tiv.2017.11.016. Epub 2017 Dec 5. Toxicol In Vitro. 2018. PMID: 29203341 Free PMC article. Review.

2

Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making.

Paini A, Leonard JA, Joossens E, Bessems JGM, Desalegn A, Dorne JL, Gosling JP, Heringa MB, Klaric M, Kliment T, Kramer NI, Loizou G, Louisse J, Lumen A, Madden JC, Patterson EA, Proença S, Punt A, Setzer RW, Suciu N, Troutman J, Yoon M, Worth A, Tan YM. Paini A, et al. Among authors: troutman j. Comput Toxicol. 2019 Feb;9:61-72. doi: 10.1016/j.comtox.2018.11.002. Comput Toxicol. 2019. PMID: 31008414 Free PMC article. Review.

3

The incorporation of lysine into the peroxidase peptide reactivity assay for skin sensitization assessments.

Troutman JA, Foertsch LM, Kern PS, Dai HJ, Quijano M, Dobson RL, Lalko JF, Lepoittevin JP, Gerberick GF. Troutman JA, et al. Toxicol Sci. 2011 Aug;122(2):422-36. doi: 10.1093/toxsci/kfr101. Epub 2011 May 9. Toxicol Sci. 2011. PMID: 21555337

4

Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro.

Manwaring J, Rothe H, Obringer C, Foltz DJ, Baker TR, Troutman JA, Hewitt NJ, Goebel C. Manwaring J, et al. Among authors: troutman ja. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):139-148. doi: 10.1016/j.taap.2015.05.016. Epub 2015 May 29. Toxicol Appl Pharmacol. 2015. PMID: 26028483 Free article.

5

Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment.

Troutman JA, Rick DL, Stuard SB, Fisher J, Bartels MJ. Troutman JA, et al. Regul Toxicol Pharmacol. 2015 Nov;73(2):530-43. doi: 10.1016/j.yrtph.2015.07.012. Epub 2015 Jul 16. Regul Toxicol Pharmacol. 2015. PMID: 26188115

6

Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism.

Lester C, Troutman J, Obringer C, Wehmeyer K, Stoffolano P, Karb M, Xu Y, Roe A, Carr G, Blackburn K, Mahony C. Lester C, et al. Among authors: troutman j. Food Chem Toxicol. 2019 Sep;131:110523. doi: 10.1016/j.fct.2019.05.031. Epub 2019 May 23. Food Chem Toxicol. 2019. PMID: 31129256

7

Estimation of in vivo dose of dermally applied chemicals leading to estrogen/androgen receptor-mediated toxicity from in vitro data--Illustration with four reproductive toxicants.

Dancik Y, Troutman JA, Jaworska J. Dancik Y, et al. Among authors: troutman ja. Reprod Toxicol. 2015 Aug 1;55:50-63. doi: 10.1016/j.reprotox.2015.01.002. Epub 2015 Jan 15. Reprod Toxicol. 2015. PMID: 25597788

8

Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction.

Goebel C, Troutman J, Hennen J, Rothe H, Schlatter H, Gerberick GF, Blömeke B. Goebel C, et al. Among authors: troutman j. Toxicol Appl Pharmacol. 2014 Feb 1;274(3):480-7. doi: 10.1016/j.taap.2013.11.016. Epub 2013 Dec 10. Toxicol Appl Pharmacol. 2014. PMID: 24333256

9

A Mechanistic Bayesian Inferential Workflow for Estimation of In Vivo Skin Permeation from In Vitro Measurements.

Hamadeh A, Troutman J, Najjar A, Edginton A. Hamadeh A, et al. Among authors: troutman j. J Pharm Sci. 2022 Mar;111(3):838-851. doi: 10.1016/j.xphs.2021.11.028. Epub 2021 Dec 4. J Pharm Sci. 2022. PMID: 34871561

10

Effect of chain length and branching on the in vitro metabolism of a series of parabens in human liver S9, human skin S9, and human plasma.

Obringer C, Wu S, Troutman J, Karb M, Lester C. Obringer C, et al. Among authors: troutman j. Regul Toxicol Pharmacol. 2021 Jun;122:104918. doi: 10.1016/j.yrtph.2021.104918. Epub 2021 Mar 17. Regul Toxicol Pharmacol. 2021. PMID: 33741472

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