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The cephalic phase of insulin release is modulated by IL-1β.
Wiedemann SJ, Trimigliozzi K, Dror E, Meier DT, Molina-Tijeras JA, Rachid L, Le Foll C, Magnan C, Schulze F, Stawiski M, Häuselmann SP, Méreau H, Böni-Schnetzler M, Donath MY. Wiedemann SJ, et al. Among authors: trimigliozzi k. Cell Metab. 2022 Jul 5;34(7):991-1003.e6. doi: 10.1016/j.cmet.2022.06.001. Epub 2022 Jun 23. Cell Metab. 2022. PMID: 35750050 Free article.
IL-1beta promotes the age-associated decline of beta cell function.
Böni-Schnetzler M, Méreau H, Rachid L, Wiedemann SJ, Schulze F, Trimigliozzi K, Meier DT, Donath MY. Böni-Schnetzler M, et al. Among authors: trimigliozzi k. iScience. 2021 Oct 9;24(11):103250. doi: 10.1016/j.isci.2021.103250. eCollection 2021 Nov 19. iScience. 2021. PMID: 34746709 Free PMC article.
Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing.
Meier DT, Rachid L, Wiedemann SJ, Traub S, Trimigliozzi K, Stawiski M, Sauteur L, Winter DV, Le Foll C, Brégère C, Guzman R, Odermatt A, Böni-Schnetzler M, Donath MY. Meier DT, et al. Among authors: trimigliozzi k. Nat Commun. 2022 Aug 13;13(1):4761. doi: 10.1038/s41467-022-32509-4. Nat Commun. 2022. PMID: 35963866 Free PMC article.