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Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase.
Cell Rep. 2023 Aug 29;42(8):112972. doi: 10.1016/j.celrep.2023.112972. Epub 2023 Aug 13.
Cell Rep. 2023.
PMID: 37578860
Free article.
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family.
Guo X, Söderholm A, Kanchugal P S, Isaksen GV, Warsi O, Eckhard U, Trigüis S, Gogoll A, Jerlström-Hultqvist J, Åqvist J, Andersson DI, Selmer M.
Guo X, et al. Among authors: triguis s.
Elife. 2021 Feb 10;10:e61818. doi: 10.7554/eLife.61818.
Elife. 2021.
PMID: 33567250
Free PMC article.
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