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SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models.
Gray E, Ulrich M, Epp A, Younan P, Sahetya D, Hensley K, Allred S, Huang LY, Hahn J, Gahnberg K, Treuting PM, Trueblood ES, Gosink JJ, Thurman R, Wo S, Spahr K, Haass EJ, Snead K, Miller D, Padilla M, Smith AJ, Frantz C, Schrum JP, Nazarenko N, Gardai SJ. Gray E, et al. Among authors: treuting pm. J Immunother Cancer. 2023 Oct;11(10):e007572. doi: 10.1136/jitc-2023-007572. J Immunother Cancer. 2023. PMID: 37793853 Free PMC article.
PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection.
Tam VC, Suen R, Treuting PM, Armando A, Lucarelli R, Gorrochotegui-Escalante N, Diercks AH, Quehenberger O, Dennis EA, Aderem A, Gold ES. Tam VC, et al. Among authors: treuting pm. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15789-15798. doi: 10.1073/pnas.2006343117. Epub 2020 Jun 24. Proc Natl Acad Sci U S A. 2020. PMID: 32581129 Free PMC article.
CFTR dysregulation drives active selection of the gut microbiome.
Meeker SM, Mears KS, Sangwan N, Brittnacher MJ, Weiss EJ, Treuting PM, Tolley N, Pope CE, Hager KR, Vo AT, Paik J, Frevert CW, Hayden HS, Hoffman LR, Miller SI, Hajjar AM. Meeker SM, et al. Among authors: treuting pm. PLoS Pathog. 2020 Jan 21;16(1):e1008251. doi: 10.1371/journal.ppat.1008251. eCollection 2020 Jan. PLoS Pathog. 2020. PMID: 31961914 Free PMC article.
STING is required for host defense against neuropathological West Nile virus infection.
McGuckin Wuertz K, Treuting PM, Hemann EA, Esser-Nobis K, Snyder AG, Graham JB, Daniels BP, Wilkins C, Snyder JM, Voss KM, Oberst A, Lund J, Gale M Jr. McGuckin Wuertz K, et al. Among authors: treuting pm. PLoS Pathog. 2019 Aug 15;15(8):e1007899. doi: 10.1371/journal.ppat.1007899. eCollection 2019 Aug. PLoS Pathog. 2019. PMID: 31415679 Free PMC article.
96 results