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Iminosugars: A host-targeted approach to combat Flaviviridae infections.
Evans DeWald L, Starr C, Butters T, Treston A, Warfield KL. Evans DeWald L, et al. Among authors: treston a. Antiviral Res. 2020 Dec;184:104881. doi: 10.1016/j.antiviral.2020.104881. Epub 2020 Aug 5. Antiviral Res. 2020. PMID: 32768411 Free PMC article. Review.
Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.
Warfield KL, Plummer EM, Sayce AC, Alonzi DS, Tang W, Tyrrell BE, Hill ML, Caputo AT, Killingbeck SS, Beatty PR, Harris E, Iwaki R, Kinami K, Ide D, Kiappes JL, Kato A, Buck MD, King K, Eddy W, Khaliq M, Sampath A, Treston AM, Dwek RA, Enterlein SG, Miller JL, Zitzmann N, Ramstedt U, Shresta S. Warfield KL, et al. Among authors: treston am. Antiviral Res. 2016 May;129:93-98. doi: 10.1016/j.antiviral.2016.03.001. Epub 2016 Mar 3. Antiviral Res. 2016. PMID: 26946111 Free PMC article.
Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo.
Warfield KL, Warren TK, Qiu X, Wells J, Mire CE, Geisbert JB, Stuthman KS, Garza NL, Van Tongeren SA, Shurtleff AC, Agans KN, Wong G, Callahan MV, Geisbert TW, Klose B, Ramstedt U, Treston AM. Warfield KL, et al. Among authors: treston am. Antiviral Res. 2017 Feb;138:22-31. doi: 10.1016/j.antiviral.2016.11.019. Epub 2016 Nov 28. Antiviral Res. 2017. PMID: 27908828
GC-072: A Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens.
Shearer JD, Saylor ML, Butler CM, Treston AM, Heine HS, Chirakul S, Schweizer HP, Louie A, Drusano GL, Zumbrun SD, Warfield KL. Shearer JD, et al. Among authors: treston am. Antimicrob Agents Chemother. 2019 Sep 9;63(12):e00834-19. doi: 10.1128/AAC.00834-19. Epub 2019 Sep 23. Antimicrob Agents Chemother. 2019. PMID: 31548183 Free PMC article.
Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections.
Warfield KL, Alonzi DS, Hill JC, Caputo AT, Roversi P, Kiappes JL, Sheets N, Duchars M, Dwek RA, Biggins J, Barnard D, Shresta S, Treston AM, Zitzmann N. Warfield KL, et al. Among authors: treston am. J Med Chem. 2020 Apr 23;63(8):4205-4214. doi: 10.1021/acs.jmedchem.0c00067. Epub 2020 Apr 15. J Med Chem. 2020. PMID: 32227946
Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.
Callahan M, Treston AM, Lin G, Smith M, Kaufman B, Khaliq M, Evans DeWald L, Spurgers K, Warfield KL, Lowe P, Duchars M, Sampath A, Ramstedt U. Callahan M, et al. Among authors: treston am. PLoS Negl Trop Dis. 2022 Aug 8;16(8):e0010636. doi: 10.1371/journal.pntd.0010636. eCollection 2022 Aug. PLoS Negl Trop Dis. 2022. PMID: 35939501 Free PMC article. Clinical Trial.
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