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Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling.
Schneider KM, Candels LS, Hov JR, Myllys M, Hassan R, Schneider CV, Wahlström A, Mohs A, Zühlke S, Liao L, Elfers C, Kilic K, Henricsson M, Molinaro A, Hatting M, Zaza A, Drasdo D, Frissen M, Devlin AS, Gálvez EJC, Strowig T, Karlsen TH, Hengstler JG, Marschall HU, Ghallab A, Trautwein C. Schneider KM, et al. Among authors: trautwein c. Nat Metab. 2021 Sep;3(9):1228-1241. doi: 10.1038/s42255-021-00452-1. Epub 2021 Sep 22. Nat Metab. 2021. PMID: 34552267
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.
Schneider KM, Mohs A, Gui W, Galvez EJC, Candels LS, Hoenicke L, Muthukumarasamy U, Holland CH, Elfers C, Kilic K, Schneider CV, Schierwagen R, Strnad P, Wirtz TH, Marschall HU, Latz E, Lelouvier B, Saez-Rodriguez J, de Vos W, Strowig T, Trebicka J, Trautwein C. Schneider KM, et al. Among authors: trautwein c. Nat Commun. 2022 Jul 8;13(1):3964. doi: 10.1038/s41467-022-31312-5. Nat Commun. 2022. PMID: 35803930 Free PMC article.
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis.
Gui W, Hole MJ, Molinaro A, Edlund K, Jørgensen KK, Su H, Begher-Tibbe B, Gaßler N, Schneider CV, Muthukumarasamy U, Mohs A, Liao L, Jaeger J, Mertens CJ, Bergheim I, Strowig T, Hengstler JG, Hov JR, Marschall HU, Trautwein C, Schneider KM. Gui W, et al. Among authors: trautwein c. Nat Commun. 2023 Jun 6;14(1):3304. doi: 10.1038/s41467-023-38840-8. Nat Commun. 2023. PMID: 37280200 Free PMC article.
Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice.
Otto J, Verwaayen A, Penners C, Hundertmark J, Lin C, Kallen C, Paffen D, Otto T, Berger H, Tacke F, Weiskirchen R, Nevzorova YA, Bartneck M, Trautwein C, Sonntag R, Liedtke C. Otto J, et al. Among authors: trautwein c. Cell Death Dis. 2023 Aug 24;14(8):549. doi: 10.1038/s41419-023-06077-4. Cell Death Dis. 2023. PMID: 37620309 Free PMC article.
842 results