Trapani JA - Search Results

1

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.

Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, McEwen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A. Witkowski M, et al. Among authors: trapani ja. Nature. 2021 Dec;600(7888):295-301. doi: 10.1038/s41586-021-04142-6. Epub 2021 Oct 25. Nature. 2021. PMID: 34695836

2

The structural basis for membrane binding and pore formation by lymphocyte perforin.

Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC. Law RH, et al. Among authors: trapani ja. Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31. Nature. 2010. PMID: 21037563

3

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance.

Fareh M, Zhao W, Hu W, Casan JML, Kumar A, Symons J, Zerbato JM, Fong D, Voskoboinik I, Ekert PG, Rudraraju R, Purcell DFJ, Lewin SR, Trapani JA. Fareh M, et al. Among authors: trapani ja. Nat Commun. 2021 Jul 13;12(1):4270. doi: 10.1038/s41467-021-24577-9. Nat Commun. 2021. PMID: 34257311 Free PMC article.

4

Functional significance of the perforin/granzyme cell death pathway.

Trapani JA, Smyth MJ. Trapani JA, et al. Nat Rev Immunol. 2002 Oct;2(10):735-47. doi: 10.1038/nri911. Nat Rev Immunol. 2002. PMID: 12360212 Review.

5

Perforin-mediated target-cell death and immune homeostasis.

Voskoboinik I, Smyth MJ, Trapani JA. Voskoboinik I, et al. Among authors: trapani ja. Nat Rev Immunol. 2006 Dec;6(12):940-52. doi: 10.1038/nri1983. Nat Rev Immunol. 2006. PMID: 17124515 Review.

6

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.

Sedelies KA, Ciccone A, Clarke CJ, Oliaro J, Sutton VR, Scott FL, Silke J, Susanto O, Green DR, Johnstone RW, Bird PI, Trapani JA, Waterhouse NJ. Sedelies KA, et al. Among authors: trapani ja. Cell Death Differ. 2008 Apr;15(4):708-17. doi: 10.1038/sj.cdd.4402300. Epub 2008 Jan 18. Cell Death Differ. 2008. PMID: 18202705

7

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice.

Jenkins MR, Trapani JA, Doherty PC, Turner SJ. Jenkins MR, et al. Among authors: trapani ja. Viral Immunol. 2008 Sep;21(3):341-6. doi: 10.1089/vim.2008.0036. Viral Immunol. 2008. PMID: 18788942

8

A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

Anthony DA, Andrews DM, Chow M, Watt SV, House C, Akira S, Bird PI, Trapani JA, Smyth MJ. Anthony DA, et al. Among authors: trapani ja. J Immunol. 2010 Aug 1;185(3):1794-803. doi: 10.4049/jimmunol.1000430. Epub 2010 Jun 28. J Immunol. 2010. PMID: 20585036

9

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy.

Hsu AK, Quach H, Tai T, Prince HM, Harrison SJ, Trapani JA, Smyth MJ, Neeson P, Ritchie DS. Hsu AK, et al. Among authors: trapani ja. Blood. 2011 Feb 3;117(5):1605-13. doi: 10.1182/blood-2010-04-278432. Epub 2010 Oct 26. Blood. 2011. PMID: 20978269 Free article.

10

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Lopez JA, Jenkins MR, Rudd-Schmidt JA, Brennan AJ, Danne JC, Mannering SI, Trapani JA, Voskoboinik I. Lopez JA, et al. Among authors: trapani ja. J Immunol. 2013 Sep 1;191(5):2328-34. doi: 10.4049/jimmunol.1301205. Epub 2013 Jul 24. J Immunol. 2013. PMID: 23885110

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