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Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells.
Alpuche-Lazcano SP, Stuible M, Akache B, Tran A, Kelly J, Hrapovic S, Robotham A, Haqqani A, Star A, Renner TM, Blouin J, Maltais JS, Cass B, Cui K, Cho JY, Wang X, Zoubchenok D, Dudani R, Duque D, McCluskie MJ, Durocher Y. Alpuche-Lazcano SP, et al. Among authors: tran a. Commun Med (Lond). 2023 Aug 23;3(1):116. doi: 10.1038/s43856-023-00340-7. Commun Med (Lond). 2023. PMID: 37612423 Free PMC article.
An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity.
Fluckiger AC, Ontsouka B, Bozic J, Diress A, Ahmed T, Berthoud T, Tran A, Duque D, Liao M, McCluskie M, Diaz-Mitoma F, Anderson DE, Soare C. Fluckiger AC, et al. Among authors: tran a. Vaccine. 2021 Aug 16;39(35):4988-5001. doi: 10.1016/j.vaccine.2021.07.034. Epub 2021 Jul 16. Vaccine. 2021. PMID: 34304928 Free PMC article.
Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant.
Akache B, Renner TM, Tran A, Deschatelets L, Dudani R, Harrison BA, Duque D, Haukenfrers J, Rossotti MA, Gaudreault F, Hemraz UD, Lam E, Régnier S, Chen W, Gervais C, Stuible M, Krishnan L, Durocher Y, McCluskie MJ. Akache B, et al. Among authors: tran a. Sci Rep. 2021 Nov 8;11(1):21849. doi: 10.1038/s41598-021-01363-7. Sci Rep. 2021. PMID: 34750472 Free PMC article.
DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster Model.
Tamming LA, Duque D, Tran A, Zhang W, Pfeifle A, Laryea E, Wu J, Raman SNT, Gravel C, Russell MS, Hashem AM, Alsulaiman RM, Alhabbab RY, Gao J, Safronetz D, Cao J, Wang L, Chen W, Johnston MJW, Sauve S, Rosu-Myles M, Li X. Tamming LA, et al. Among authors: tran a. Front Immunol. 2022 Jan 12;12:785349. doi: 10.3389/fimmu.2021.785349. eCollection 2021. Front Immunol. 2022. PMID: 35095861 Free PMC article.
Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters.
Stark FC, Akache B, Deschatelets L, Tran A, Stuible M, Durocher Y, McCluskie MJ, Agbayani G, Dudani R, Harrison BA, Renner TM, Makinen SR, Bavananthasivam J, Duque D, Gagne M, Zimmermann J, Zarley CD, Cochrane TR, Handfield M. Stark FC, et al. Among authors: tran a. Sci Rep. 2022 Jun 13;12(1):9772. doi: 10.1038/s41598-022-13819-5. Sci Rep. 2022. PMID: 35697917 Free PMC article.
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models.
Rossotti MA, van Faassen H, Tran AT, Sheff J, Sandhu JK, Duque D, Hewitt M, Wen X, Bavananthasivam J, Beitari S, Matte K, Laroche G, Giguère PM, Gervais C, Stuible M, Guimond J, Perret S, Hussack G, Langlois MA, Durocher Y, Tanha J. Rossotti MA, et al. Among authors: tran at. Commun Biol. 2022 Sep 9;5(1):933. doi: 10.1038/s42003-022-03866-z. Commun Biol. 2022. PMID: 36085335 Free PMC article.
Intranasal administration of unadjuvanted SARS-CoV-2 spike antigen boosts antigen-specific immune responses induced by parenteral protein subunit vaccine prime in mice and hamsters.
Agbayani G, Akache B, Renner TM, Tran A, Stuible M, Dudani R, Harrison BA, Duque D, Bavananthasivam J, Deschatelets L, Hemraz UD, Régnier S, Durocher Y, McCluskie MJ. Agbayani G, et al. Among authors: tran a. Eur J Immunol. 2024 Apr 1:e2350620. doi: 10.1002/eji.202350620. Online ahead of print. Eur J Immunol. 2024. PMID: 38561974
2,178 results