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A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.
Tan TK, Rijal P, Rahikainen R, Keeble AH, Schimanski L, Hussain S, Harvey R, Hayes JWP, Edwards JC, McLean RK, Martini V, Pedrera M, Thakur N, Conceicao C, Dietrich I, Shelton H, Ludi A, Wilsden G, Browning C, Zagrajek AK, Bialy D, Bhat S, Stevenson-Leggett P, Hollinghurst P, Tully M, Moffat K, Chiu C, Waters R, Gray A, Azhar M, Mioulet V, Newman J, Asfor AS, Burman A, Crossley S, Hammond JA, Tchilian E, Charleston B, Bailey D, Tuthill TJ, Graham SP, Duyvesteyn HME, Malinauskas T, Huo J, Tree JA, Buttigieg KR, Owens RJ, Carroll MW, Daniels RS, McCauley JW, Stuart DI, Huang KA, Howarth M, Townsend AR. Tan TK, et al. Among authors: townsend ar. Nat Commun. 2021 Jan 22;12(1):542. doi: 10.1038/s41467-020-20654-7. Nat Commun. 2021. PMID: 33483491 Free PMC article.
The hemochromatosis protein HFE inhibits iron export from macrophages.
Drakesmith H, Sweetland E, Schimanski L, Edwards J, Cowley D, Ashraf M, Bastin J, Townsend AR. Drakesmith H, et al. Among authors: townsend ar. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15602-7. doi: 10.1073/pnas.242614699. Epub 2002 Nov 12. Proc Natl Acad Sci U S A. 2002. PMID: 12429850 Free PMC article.
In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor.
Schimanski LM, Drakesmith H, Sweetland E, Bastin J, Rezgui D, Edelmann M, Kessler B, Merryweather-Clarke AT, Robson KJ, Townsend AR. Schimanski LM, et al. Among authors: townsend ar. Blood Cells Mol Dis. 2009 Sep-Oct;43(2):180-93. doi: 10.1016/j.bcmd.2009.03.010. Epub 2009 May 31. Blood Cells Mol Dis. 2009. PMID: 19487139
Focused antibody response to influenza linked to antigenic drift.
Huang KY, Rijal P, Schimanski L, Powell TJ, Lin TY, McCauley JW, Daniels RS, Townsend AR. Huang KY, et al. Among authors: townsend ar. J Clin Invest. 2015 Jul 1;125(7):2631-45. doi: 10.1172/JCI81104. Epub 2015 May 26. J Clin Invest. 2015. PMID: 26011643 Free PMC article.
Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.
Tungatt K, Dolton G, Morgan SB, Attaf M, Fuller A, Whalley T, Hemmink JD, Porter E, Szomolay B, Montoya M, Hammond JA, Miles JJ, Cole DK, Townsend A, Bailey M, Rizkallah PJ, Charleston B, Tchilian E, Sewell AK. Tungatt K, et al. PLoS Pathog. 2018 May 17;14(5):e1007017. doi: 10.1371/journal.ppat.1007017. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29772011 Free PMC article.
263 results