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MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer.
Alburquerque-Bejar JJ, Navajas-Chocarro P, Saigi M, Ferrero-Andres A, Morillas JM, Vilarrubi A, Gomez A, Mate JL, Munoz-Marmol AM, Romero OA, Blecua P, Davalos V, Esteller M, Pros E, Llabata P, Torres-Diz M, Esteve-Codina A, Sanchez-Cespedes M. Alburquerque-Bejar JJ, et al. Among authors: torres diz m. Cell Rep Med. 2023 Apr 18;4(4):101006. doi: 10.1016/j.xcrm.2023.101006. Epub 2023 Apr 11. Cell Rep Med. 2023. PMID: 37044092 Free PMC article.
MAX mutant small-cell lung cancers exhibit impaired activities of MGA-dependent noncanonical polycomb repressive complex.
Llabata P, Torres-Diz M, Gomez A, Tomas-Daza L, Romero OA, Grego-Bessa J, Llinas-Arias P, Valencia A, Esteller M, Javierre BM, Zhang X, Sanchez-Cespedes M. Llabata P, et al. Among authors: torres diz m. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2024824118. doi: 10.1073/pnas.2024824118. Proc Natl Acad Sci U S A. 2021. PMID: 34493659 Free PMC article.
Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma.
Llabata P, Mitsuishi Y, Choi PS, Cai D, Francis JM, Torres-Diz M, Udeshi ND, Golomb L, Wu Z, Zhou J, Svinkina T, Aguilera-Jimenez E, Liu Y, Carr SA, Sanchez-Cespedes M, Meyerson M, Zhang X. Llabata P, et al. Mol Cancer Res. 2020 Apr;18(4):574-584. doi: 10.1158/1541-7786.MCR-19-0657. Epub 2019 Dec 20. Mol Cancer Res. 2020. PMID: 31862696 Free PMC article.
Alternative splicing of its 5'-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies.
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Torres Diz M, Xu F, Zankharia U, Zhang Y, Soldan S, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Asnani M, King Sainos P, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A. Ang Z, et al. Among authors: torres diz m. Blood. 2023 Nov 16;142(20):1724-1739. doi: 10.1182/blood.2023020400. Blood. 2023. PMID: 37683180 Free PMC article.
Alternative splicing of its 5'-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies.
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Torres Diz M, Xu F, Zankharia U, Zhang Y, Soldan S, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Asnani M, King Sainos P, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A. Ang Z, et al. Among authors: torres diz m. bioRxiv [Preprint]. 2023 Aug 16:2023.02.19.529123. doi: 10.1101/2023.02.19.529123. bioRxiv. 2023. PMID: 37645778 Free PMC article. Updated. Preprint.
A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1.
Closa A, Reixachs-Solé M, Fuentes-Fayos AC, Hayer KE, Melero JL, Adriaanse FRS, Bos RS, Torres-Diz M, Hunger SP, Roberts KG, Mullighan CG, Stam RW, Thomas-Tikhonenko A, Castaño JP, Luque RM, Eyras E. Closa A, et al. Among authors: torres diz m. NAR Cancer. 2022 Dec 9;4(4):zcac041. doi: 10.1093/narcan/zcac041. eCollection 2022 Dec. NAR Cancer. 2022. PMID: 36518527 Free PMC article.
High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance.
Cortés-López M, Schulz L, Enculescu M, Paret C, Spiekermann B, Quesnel-Vallières M, Torres-Diz M, Unic S, Busch A, Orekhova A, Kuban M, Mesitov M, Mulorz MM, Shraim R, Kielisch F, Faber J, Barash Y, Thomas-Tikhonenko A, Zarnack K, Legewie S, König J. Cortés-López M, et al. Among authors: torres diz m. Nat Commun. 2022 Sep 22;13(1):5570. doi: 10.1038/s41467-022-31818-y. Nat Commun. 2022. PMID: 36138008 Free PMC article.
13 results