Toretsky JA - Search Results

1

EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.

Gorthi A, Romero JC, Loranc E, Cao L, Lawrence LA, Goodale E, Iniguez AB, Bernard X, Masamsetti VP, Roston S, Lawlor ER, Toretsky JA, Stegmaier K, Lessnick SL, Chen Y, Bishop AJR. Gorthi A, et al. Among authors: toretsky ja. Nature. 2018 Mar 15;555(7696):387-391. doi: 10.1038/nature25748. Epub 2018 Mar 7. Nature. 2018. PMID: 29513652 Free PMC article.

2

Recombinant EWS-FLI1 oncoprotein activates transcription.

Uren A, Tcherkasskaya O, Toretsky JA. Uren A, et al. Among authors: toretsky ja. Biochemistry. 2004 Oct 26;43(42):13579-89. doi: 10.1021/bi048776q. Biochemistry. 2004. PMID: 15491164

3

PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis.

Abaan OD, Levenson A, Khan O, Furth PA, Uren A, Toretsky JA. Abaan OD, et al. Among authors: toretsky ja. Oncogene. 2005 Apr 14;24(16):2715-22. doi: 10.1038/sj.onc.1208247. Oncogene. 2005. PMID: 15782144

4

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

Uren A, Toretsky JA. Uren A, et al. Among authors: toretsky ja. Future Oncol. 2005 Aug;1(4):521-8. doi: 10.2217/14796694.1.4.521. Future Oncol. 2005. PMID: 16556028 Review.

5

Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

Toretsky JA, Erkizan V, Levenson A, Abaan OD, Parvin JD, Cripe TP, Rice AM, Lee SB, Uren A. Toretsky JA, et al. Cancer Res. 2006 Jun 1;66(11):5574-81. doi: 10.1158/0008-5472.CAN-05-3293. Cancer Res. 2006. PMID: 16740692

6

Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo.

Aryee DN, Kreppel M, Bachmaier R, Uren A, Muehlbacher K, Wagner S, Breiteneder H, Ban J, Toretsky JA, Kovar H. Aryee DN, et al. Among authors: toretsky ja. Cancer Res. 2006 Oct 15;66(20):9862-9. doi: 10.1158/0008-5472.CAN-05-4042. Cancer Res. 2006. PMID: 17047047

7

GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.

Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A. Beauchamp E, et al. J Biol Chem. 2009 Apr 3;284(14):9074-82. doi: 10.1074/jbc.M806233200. Epub 2009 Feb 3. J Biol Chem. 2009. PMID: 19189974 Free PMC article.

8

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.

Erkizan HV, Kong Y, Merchant M, Schlottmann S, Barber-Rotenberg JS, Yuan L, Abaan OD, Chou TH, Dakshanamurthy S, Brown ML, Uren A, Toretsky JA. Erkizan HV, et al. Among authors: toretsky ja. Nat Med. 2009 Jul;15(7):750-6. doi: 10.1038/nm.1983. Epub 2009 Jul 5. Nat Med. 2009. PMID: 19584866 Free PMC article.

9

Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma.

Erkizan HV, Uversky VN, Toretsky JA. Erkizan HV, et al. Among authors: toretsky ja. Clin Cancer Res. 2010 Aug 15;16(16):4077-83. doi: 10.1158/1078-0432.CCR-09-2261. Epub 2010 Jun 14. Clin Cancer Res. 2010. PMID: 20547696 Free PMC article. Review.

10

High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.

Awad O, Yustein JT, Shah P, Gul N, Katuri V, O'Neill A, Kong Y, Brown ML, Toretsky JA, Loeb DM. Awad O, et al. Among authors: toretsky ja. PLoS One. 2010 Nov 11;5(11):e13943. doi: 10.1371/journal.pone.0013943. PLoS One. 2010. PMID: 21085683 Free PMC article.

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