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Page 1
Synergistic effects of common schizophrenia risk variants.
Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H, Sklar P, Brennand KJ. Schrode N, et al. Among authors: topol a. Nat Genet. 2019 Oct;51(10):1475-1485. doi: 10.1038/s41588-019-0497-5. Epub 2019 Sep 23. Nat Genet. 2019. PMID: 31548722 Free PMC article.
Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.
Topol A, English JA, Flaherty E, Rajarajan P, Hartley BJ, Gupta S, Desland F, Zhu S, Goff T, Friedman L, Rapoport J, Felsenfeld D, Cagney G, Mackay-Sim A, Savas JN, Aronow B, Fang G, Zhang B, Cotter D, Brennand KJ. Topol A, et al. Transl Psychiatry. 2015 Oct 20;5(10):e662. doi: 10.1038/tp.2015.118. Transl Psychiatry. 2015. PMID: 26485546 Free PMC article.
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells.
Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. Topol A, et al. Cell Rep. 2016 May 3;15(5):1024-1036. doi: 10.1016/j.celrep.2016.03.090. Epub 2016 Apr 21. Cell Rep. 2016. PMID: 27117414 Free PMC article.
Gene expression elucidates functional impact of polygenic risk for schizophrenia.
Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gümüş ZH, Cicek AE, Dang KK, Browne A, Lu C, Xie L, Readhead B, Stahl EA, Xiao J, Parvizi M, Hamamsy T, Fullard JF, Wang YC, Mahajan MC, Derry JM, Dudley JT, Hemby SE, Logsdon BA, Talbot K, Raj T, Bennett DA, De Jager PL, Zhu J, Zhang B, Sullivan PF, Chess A, Purcell SM, Shinobu LA, Mangravite LM, Toyoshiba H, Gur RE, Hahn CG, Lewis DA, Haroutunian V, Peters MA, Lipska BK, Buxbaum JD, Schadt EE, Hirai K, Roeder K, Brennand KJ, Katsanis N, Domenici E, Devlin B, Sklar P. Fromer M, et al. Among authors: topol a. Nat Neurosci. 2016 Nov;19(11):1442-1453. doi: 10.1038/nn.4399. Epub 2016 Sep 26. Nat Neurosci. 2016. PMID: 27668389 Free PMC article.
Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia.
Farrelly LA, Zheng S, Schrode N, Topol A, Bhanu NV, Bastle RM, Ramakrishnan A, Chan JC, Cetin B, Flaherty E, Shen L, Gleason K, Tamminga CA, Garcia BA, Li H, Brennand KJ, Maze I. Farrelly LA, et al. Among authors: topol a. Nat Commun. 2022 Apr 22;13(1):2195. doi: 10.1038/s41467-022-29922-0. Nat Commun. 2022. PMID: 35459277 Free PMC article.
Neural stem and progenitor cells in health and disease.
Ladran I, Tran N, Topol A, Brennand KJ. Ladran I, et al. Among authors: topol a. Wiley Interdiscip Rev Syst Biol Med. 2013 Nov-Dec;5(6):701-15. doi: 10.1002/wsbm.1239. Epub 2013 Sep 20. Wiley Interdiscip Rev Syst Biol Med. 2013. PMID: 24068527 Free PMC article. Review.
Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.
Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Xu J, et al. Among authors: topol a. Mol Psychiatry. 2018 Feb;23(2):271-281. doi: 10.1038/mp.2016.163. Epub 2016 Oct 18. Mol Psychiatry. 2018. PMID: 27752082 Free PMC article.
21 results