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A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell MC, Lopes-Paciencia S, Papadopoli D, Fouillen A, Ponce KJ, Huot G, Mignacca L, Benfdil M, Kalegari P, Wahba HM, Pencik J, Vuong N, Quenneville J, Guillon J, Bourdeau V, Hulea L, Gagnon E, Kenner L, Moriggl R, Nanci A, Pollak MN, Omichinski JG, Topisirovic I, Ferbeyre G. Igelmann S, et al. Among authors: topisirovic i. Mol Cell. 2021 Sep 16;81(18):3848-3865.e19. doi: 10.1016/j.molcel.2021.08.028. Mol Cell. 2021. PMID: 34547241 Free article.
Distinct perturbation of the translatome by the antidiabetic drug metformin.
Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ, Pollak M, Sonenberg N. Larsson O, et al. Among authors: topisirovic i. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8977-82. doi: 10.1073/pnas.1201689109. Epub 2012 May 18. Proc Natl Acad Sci U S A. 2012. PMID: 22611195 Free PMC article.
Serine deprivation enhances antineoplastic activity of biguanides.
Gravel SP, Hulea L, Toban N, Birman E, Blouin MJ, Zakikhani M, Zhao Y, Topisirovic I, St-Pierre J, Pollak M. Gravel SP, et al. Among authors: topisirovic i. Cancer Res. 2014 Dec 15;74(24):7521-33. doi: 10.1158/0008-5472.CAN-14-2643-T. Epub 2014 Nov 6. Cancer Res. 2014. PMID: 25377470
Targeting the translation machinery in cancer.
Bhat M, Robichaud N, Hulea L, Sonenberg N, Pelletier J, Topisirovic I. Bhat M, et al. Among authors: topisirovic i. Nat Rev Drug Discov. 2015 Apr;14(4):261-78. doi: 10.1038/nrd4505. Epub 2015 Mar 6. Nat Rev Drug Discov. 2015. PMID: 25743081 Review.
Biomedical Potential of mTOR Modulation by Nanoparticles.
Hulea L, Markovic Z, Topisirovic I, Simmet T, Trajkovic V. Hulea L, et al. Among authors: topisirovic i. Trends Biotechnol. 2016 May;34(5):349-353. doi: 10.1016/j.tibtech.2016.01.005. Epub 2016 Feb 15. Trends Biotechnol. 2016. PMID: 26900005
mTOR-sensitive translation: Cleared fog reveals more trees.
Masvidal L, Hulea L, Furic L, Topisirovic I, Larsson O. Masvidal L, et al. Among authors: topisirovic i. RNA Biol. 2017 Oct 3;14(10):1299-1305. doi: 10.1080/15476286.2017.1290041. Epub 2017 Feb 10. RNA Biol. 2017. PMID: 28277937 Free PMC article. Review.
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.
Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, Bergeron JJ, Sonenberg N. Morita M, et al. Among authors: topisirovic i. Mol Cell. 2017 Sep 21;67(6):922-935.e5. doi: 10.1016/j.molcel.2017.08.013. Epub 2017 Sep 14. Mol Cell. 2017. PMID: 28918902 Free article.
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