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Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives.
Barbieri F, Bosio AG, Pattarozzi A, Tonelli M, Bajetto A, Verduci I, Cianci F, Cannavale G, Palloni LMG, Francesconi V, Thellung S, Fiaschi P, Mazzetti S, Schenone S, Balboni B, Girotto S, Malatesta P, Daga A, Zona G, Mazzanti M, Florio T. Barbieri F, et al. Among authors: tonelli m. J Exp Clin Cancer Res. 2022 Feb 8;41(1):53. doi: 10.1186/s13046-021-02213-0. J Exp Clin Cancer Res. 2022. PMID: 35135603 Free PMC article.
Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide.
Villa V, Thellung S, Bajetto A, Gatta E, Robello M, Novelli F, Tasso B, Tonelli M, Florio T. Villa V, et al. Among authors: tonelli m. Pharmacol Res. 2016 Nov;113(Pt A):500-514. doi: 10.1016/j.phrs.2016.09.010. Epub 2016 Sep 22. Pharmacol Res. 2016. PMID: 27667770
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR).
Francesconi V, Giovannini L, Santucci M, Cichero E, Costi MP, Naesens L, Giordanetto F, Tonelli M. Francesconi V, et al. Among authors: tonelli m. Eur J Med Chem. 2018 Jul 15;155:229-243. doi: 10.1016/j.ejmech.2018.05.059. Epub 2018 Jun 2. Eur J Med Chem. 2018. PMID: 29886325 Free PMC article.
Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability.
Barbieri F, Würth R, Pattarozzi A, Verduci I, Mazzola C, Cattaneo MG, Tonelli M, Solari A, Bajetto A, Daga A, Vicentini LM, Mazzanti M, Florio T. Barbieri F, et al. Among authors: tonelli m. Front Pharmacol. 2018 Aug 21;9:899. doi: 10.3389/fphar.2018.00899. eCollection 2018. Front Pharmacol. 2018. PMID: 30186163 Free PMC article.
1,319 results