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Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1.
Moyer BJ, Rojas IY, Kerley-Hamilton JS, Hazlett HF, Nemani KV, Trask HW, West RJ, Lupien LE, Collins AJ, Ringelberg CS, Gimi B, Kinlaw WB 3rd, Tomlinson CR. Moyer BJ, et al. Among authors: tomlinson cr. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24. doi: 10.1016/j.taap.2016.03.011. Epub 2016 Mar 25. Toxicol Appl Pharmacol. 2016. PMID: 27020609 Free PMC article.
Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet.
Kerley-Hamilton JS, Trask HW, Ridley CJ, Dufour E, Ringelberg CS, Nurinova N, Wong D, Moodie KL, Shipman SL, Moore JH, Korc M, Shworak NW, Tomlinson CR. Kerley-Hamilton JS, et al. Among authors: tomlinson cr. Environ Health Perspect. 2012 Sep;120(9):1252-9. doi: 10.1289/ehp.1205003. Epub 2012 May 18. Environ Health Perspect. 2012. PMID: 22609946 Free PMC article.
Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice.
Kerley-Hamilton JS, Trask HW, Ridley CJ, Dufour E, Lesseur C, Ringelberg CS, Moodie KL, Shipman SL, Korc M, Gui J, Shworak NW, Tomlinson CR. Kerley-Hamilton JS, et al. Among authors: tomlinson cr. Toxicol Sci. 2012 Apr;126(2):391-404. doi: 10.1093/toxsci/kfs002. Epub 2012 Jan 6. Toxicol Sci. 2012. PMID: 22228805 Free PMC article.
Obesity I: Overview and molecular and biochemical mechanisms.
Lustig RH, Collier D, Kassotis C, Roepke TA, Kim MJ, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ. Lustig RH, et al. Among authors: tomlinson cr. Biochem Pharmacol. 2022 May;199:115012. doi: 10.1016/j.bcp.2022.115012. Epub 2022 Apr 5. Biochem Pharmacol. 2022. PMID: 35393120 Free PMC article. Review.
68 results