Tomasz M - Search Results

1

Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C.

Palom Y, Suresh Kumar G, Tang LQ, Paz MM, Musser SM, Rockwell S, Tomasz M. Palom Y, et al. Among authors: tomasz m. Chem Res Toxicol. 2002 Nov;15(11):1398-406. doi: 10.1021/tx020044g. Chem Res Toxicol. 2002. PMID: 12437330

2

Mitomycin dimers: polyfunctional cross-linkers of DNA.

Paz MM, Kumar GS, Glover M, Waring MJ, Tomasz M. Paz MM, et al. Among authors: tomasz m. J Med Chem. 2004 Jun 3;47(12):3308-19. doi: 10.1021/jm049863j. J Med Chem. 2004. PMID: 15163210

3

Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/ electrospray tandem mass spectrometry.

Paz MM, Ladwa S, Champeil E, Liu Y, Rockwell S, Boamah EK, Bargonetti J, Callahan J, Roach J, Tomasz M. Paz MM, et al. Among authors: tomasz m. Chem Res Toxicol. 2008 Dec;21(12):2370-8. doi: 10.1021/tx8002615. Chem Res Toxicol. 2008. PMID: 19053323 Free PMC article.

4

The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity.

Tomasz M, Palom Y. Tomasz M, et al. Pharmacol Ther. 1997 Oct-Dec;76(1-3):73-87. doi: 10.1016/s0163-7258(97)00088-0. Pharmacol Ther. 1997. PMID: 9535170 Review.

5

A mitomycin-N6-deoxyadenosine adduct isolated from DNA.

Palom Y, Lipman R, Musser SM, Tomasz M. Palom Y, et al. Among authors: tomasz m. Chem Res Toxicol. 1998 Mar;11(3):203-10. doi: 10.1021/tx970205u. Chem Res Toxicol. 1998. PMID: 9544618

However, the HPLC elution time of 8 coincides with that of a major, unknown MC adduct detected previously in mouse mammary tumor cells treated with radiolabeled MC [Bizanek, R., Chowdary, D., Arai, H., Kasai, M., Hughes, C. S., Sartorelli, A. C., Rockwell, S., and Tomas …

However, the HPLC elution time of 8 coincides with that of a major, unknown MC adduct detected previously in mouse mammary tumor cells treat …

6

Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.

Palom Y, Belcourt MF, Kumar GS, Arai H, Kasai M, Sartorelli AC, Rockwell S, Tomasz M. Palom Y, et al. Among authors: tomasz m. Oncol Res. 1998;10(10):509-21. Oncol Res. 1998. PMID: 10338154

7

Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity.

Paz MM, Das TA, Tomasz M. Paz MM, et al. Among authors: tomasz m. Bioorg Med Chem. 1999 Dec;7(12):2713-26. doi: 10.1016/s0968-0896(99)00223-0. Bioorg Med Chem. 1999. PMID: 10658576

8

Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells.

Palom Y, Belcourt MF, Musser SM, Sartorelli AC, Rockwell S, Tomasz M. Palom Y, et al. Among authors: tomasz m. Chem Res Toxicol. 2000 Jun;13(6):479-88. doi: 10.1021/tx000024j. Chem Res Toxicol. 2000. PMID: 10858321

9

Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.

Palom Y, Belcourt MF, Tang LQ, Mehta SS, Sartorelli AC, Pritsos CA, Pritsos KL, Rockwell S, Tomasz M. Palom Y, et al. Among authors: tomasz m. Biochem Pharmacol. 2001 Jun 15;61(12):1517-29. doi: 10.1016/s0006-2952(01)00609-8. Biochem Pharmacol. 2001. PMID: 11377381

10

Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential.

Paz MM, Das A, Palom Y, He QY, Tomasz M. Paz MM, et al. Among authors: tomasz m. J Med Chem. 2001 Aug 16;44(17):2834-42. doi: 10.1021/jm010072g. J Med Chem. 2001. PMID: 11495594

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