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PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves.
Díaz Acosta CC, Dias AA, Rosa TLSA, Batista-Silva LR, Rosa PS, Toledo-Pinto TG, Costa FDMR, Lara FA, Rodrigues LS, Mattos KA, Sarno EN, Bozza PT, Guilhot C, de Berrêdo-Pinho M, Pessolani MCV. Díaz Acosta CC, et al. Among authors: toledo pinto tg. PLoS Pathog. 2018 Jul 6;14(7):e1007151. doi: 10.1371/journal.ppat.1007151. eCollection 2018 Jul. PLoS Pathog. 2018. PMID: 29979790 Free PMC article.
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages.
Batista-Silva LR, Rodrigues LS, Vivarini Ade C, Costa Fda M, Mattos KA, Costa MR, Rosa PS, Toledo-Pinto TG, Dias AA, Moura DF, Sarno EN, Lopes UG, Pessolani MC. Batista-Silva LR, et al. Among authors: toledo pinto tg. Sci Rep. 2016 Jun 10;6:27632. doi: 10.1038/srep27632. Sci Rep. 2016. PMID: 27282338 Free PMC article.
Gene expression profiling specifies chemokine, mitochondrial and lipid metabolism signatures in leprosy.
Guerreiro LT, Robottom-Ferreira AB, Ribeiro-Alves M, Toledo-Pinto TG, Rosa Brito T, Rosa PS, Sandoval FG, Jardim MR, Antunes SG, Shannon EJ, Sarno EN, Pessolani MC, Williams DL, Moraes MO. Guerreiro LT, et al. Among authors: toledo pinto tg. PLoS One. 2013 Jun 14;8(6):e64748. doi: 10.1371/journal.pone.0064748. Print 2013. PLoS One. 2013. PMID: 23798993 Free PMC article.
Type I Interferons, Autophagy and Host Metabolism in Leprosy.
Toledo Pinto TG, Batista-Silva LR, Medeiros RCA, Lara FA, Moraes MO. Toledo Pinto TG, et al. Front Immunol. 2018 Apr 23;9:806. doi: 10.3389/fimmu.2018.00806. eCollection 2018. Front Immunol. 2018. PMID: 29755459 Free PMC article. Review.
Pre-miR-146a (rs2910164 G>C) single nucleotide polymorphism is genetically and functionally associated with leprosy.
Cezar-de-Mello PF, Toledo-Pinto TG, Marques CS, Arnez LE, Cardoso CC, Guerreiro LT, Antunes SL, Jardim MM, Covas Cde J, Illaramendi X, Dias-Baptista IM, Rosa PS, Durães SM, Pacheco AG, Ribeiro-Alves M, Sarno EN, Moraes MO. Cezar-de-Mello PF, et al. Among authors: toledo pinto tg. PLoS Negl Trop Dis. 2014 Sep 4;8(9):e3099. doi: 10.1371/journal.pntd.0003099. eCollection 2014 Sep. PLoS Negl Trop Dis. 2014. PMID: 25187983 Free PMC article.
Association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity and its functional effects.
Xavier-Carvalho C, Cezar RDDS, Freire NM, Vasconcelos CMM, Solorzano VEF, de Toledo-Pinto TG, Fialho LG, do Carmo RF, Vasconcelos LRS, Cordeiro MT, Baptista P, de Azeredo EL, da Cunha RV, de Souza LJ, Pacheco AG, Kubelka CF, Moura PMMF, Moraes MO. Xavier-Carvalho C, et al. Among authors: de toledo pinto tg. Hum Immunol. 2017 Oct;78(10):649-656. doi: 10.1016/j.humimm.2017.07.013. Epub 2017 Jul 29. Hum Immunol. 2017. PMID: 28764923
Indoleamine 2,3-dioxygenase and iron are required for Mycobacterium leprae survival.
de Mattos Barbosa MG, da Silva Prata RB, Andrade PR, Ferreira H, de Andrade Silva BJ, da Paixão de Oliveira JA, Assis TQ, de Toledo-Pinto TG, de Lima Bezerra OC, da Costa Nery JA, Rosa PS, Bozza MT, Lara FA, Moraes MO, Schmitz V, Sarno EN, Pinheiro RO. de Mattos Barbosa MG, et al. Among authors: de toledo pinto tg. Microbes Infect. 2017 Nov;19(11):505-514. doi: 10.1016/j.micinf.2017.06.006. Epub 2017 Jul 3. Microbes Infect. 2017. PMID: 28684130 Free article.
STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival.
de Toledo-Pinto TG, Ferreira AB, Ribeiro-Alves M, Rodrigues LS, Batista-Silva LR, Silva BJ, Lemes RM, Martinez AN, Sandoval FG, Alvarado-Arnez LE, Rosa PS, Shannon EJ, Pessolani MC, Pinheiro RO, Antunes SL, Sarno EN, Lara FA, Williams DL, Ozório Moraes M. de Toledo-Pinto TG, et al. J Infect Dis. 2016 Jul 15;214(2):311-20. doi: 10.1093/infdis/jiw144. Epub 2016 May 14. J Infect Dis. 2016. PMID: 27190175