Tojo H - Search Results

1

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.

Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y, Kondo S, Miyamoto M, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: tojo h. Bioorg Med Chem. 2012 Sep 15;20(18):5496-506. doi: 10.1016/j.bmc.2012.07.039. Epub 2012 Jul 31. Bioorg Med Chem. 2012. PMID: 22910224

2

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Tanaka Y, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y, Kondo S, Miyamoto M, Nishihara M, Ishimura Y, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: tojo h. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17. doi: 10.1016/j.bmc.2012.07.034. Epub 2012 Jul 27. Bioorg Med Chem. 2012. PMID: 22898254

3

Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.

Ohashi T, Tanaka Y, Shiokawa Z, Banno H, Tanaka T, Shibata S, Satoh Y, Yamakawa H, Yamamoto Y, Hattori H, Kondo S, Miyamoto M, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: tojo h. Bioorg Med Chem. 2015 Aug 1;23(15):4777-4791. doi: 10.1016/j.bmc.2015.05.036. Epub 2015 Jun 3. Bioorg Med Chem. 2015. PMID: 26094943

4

Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice.

Kogame A, Tagawa Y, Shibata S, Tojo H, Miyamoto M, Tohyama K, Kondo T, Prakash S, Shyu WC, Asahi S. Kogame A, et al. Among authors: tojo h. Drug Metab Dispos. 2013 Apr;41(4):727-34. doi: 10.1124/dmd.112.049650. Epub 2013 Jan 8. Drug Metab Dispos. 2013. PMID: 23298863

5

The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa.

Tojo H, Kaieda I, Hattori H, Katayama N, Yoshimura K, Kakimoto S, Fujisawa Y, Presman E, Brooks CC, Pilch PF. Tojo H, et al. Mol Endocrinol. 2003 Jul;17(7):1216-29. doi: 10.1210/me.2003-0056. Epub 2003 Apr 3. Mol Endocrinol. 2003. PMID: 12677009

6

TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.

Ibuki N, Ghaffari M, Pandey M, Iu I, Fazli L, Kashiwagi M, Tojo H, Nakanishi O, Gleave ME, Cox ME. Ibuki N, et al. Among authors: tojo h. Int J Cancer. 2013 Oct 15;133(8):1955-66. doi: 10.1002/ijc.28193. Epub 2013 May 6. Int J Cancer. 2013. PMID: 23564295 Free article.

7

[Assessment of oxygen transport in individual splanchnic organs using critical oxygen extraction].

Shime N, Fukui M, Yoshioka M, Sekimoto M, Tojo H, Tanaka Y. Shime N, et al. Among authors: tojo h. Masui. 1999 Aug;48(8):830-5. Masui. 1999. PMID: 10481414 Japanese.

8

Skeletal muscle injury induces hepatocyte growth factor expression in spleen.

Suzuki S, Yamanouchi K, Soeta C, Katakai Y, Harada R, Naito K, Tojo H. Suzuki S, et al. Among authors: tojo h. Biochem Biophys Res Commun. 2002 Apr 5;292(3):709-14. doi: 10.1006/bbrc.2002.6706. Biochem Biophys Res Commun. 2002. PMID: 11922624

9

[Anesthesia for a patient with alcoholic heart disease and transient complete heart block].

Tsuda N, Hirose M, Ashida H, Tojo H, Mizobe T, Tanaka Y. Tsuda N, et al. Among authors: tojo h. Masui. 2001 Oct;50(10):1126-8. Masui. 2001. PMID: 11712350 Japanese.

10

Reduction of tumorigenesis and invasion of human breast cancer cells by whey acidic protein (WAP).

Nukumi N, Iwamori T, Kano K, Naito K, Tojo H. Nukumi N, et al. Among authors: tojo h. Cancer Lett. 2007 Jul 8;252(1):65-74. doi: 10.1016/j.canlet.2006.12.005. Epub 2007 Jan 9. Cancer Lett. 2007. PMID: 17215074

We have previously found that WAP inhibits the proliferation of mammary epithelial cells in vitro and in vivo [N. Nukumi, K. Ikeda, M. Osawa, T. Iwamori, K. Naito, H. Tojo, Regulatory function of whey acidic protein in the proliferation of mouse mammary epithelial c …

We have previously found that WAP inhibits the proliferation of mammary epithelial cells in vitro and in vivo [N. Nukumi, K. Ikeda, M. Osawa …

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