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A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine.
Pharmaceutics. 2020 Dec 8;12(12):1191. doi: 10.3390/pharmaceutics12121191.
Pharmaceutics. 2020.
PMID: 33302490
Free PMC article.
CYP3A4-mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1-mediated effects on bilirubin glucuronidation in humans.
Chattopadhyay N, Kanacher T, Casjens M, Frechen S, Ligges S, Zimmermann T, Rottmann A, Ploeger B, Höchel J, Schultze-Mosgau MH.
Chattopadhyay N, et al. Among authors: kanacher t.
Br J Clin Pharmacol. 2018 Dec;84(12):2857-2866. doi: 10.1111/bcp.13750. Epub 2018 Oct 11.
Br J Clin Pharmacol. 2018.
PMID: 30171692
Free PMC article.
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Clarithromycin, Midazolam, and Digoxin: Application of PBPK Modeling to Gain New Insights into Drug-Drug Interactions and Co-medication Regimens.
Moj D, Hanke N, Britz H, Frechen S, Kanacher T, Wendl T, Haefeli WE, Lehr T.
Moj D, et al. Among authors: kanacher t.
AAPS J. 2017 Jan;19(1):298-312. doi: 10.1208/s12248-016-0009-9. Epub 2016 Nov 7.
AAPS J. 2017.
PMID: 27822600
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A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation.
Thiel C, Schneckener S, Krauss M, Ghallab A, Hofmann U, Kanacher T, Zellmer S, Gebhardt R, Hengstler JG, Kuepfer L.
Thiel C, et al. Among authors: kanacher t.
J Pharm Sci. 2015 Jan;104(1):191-206. doi: 10.1002/jps.24214. Epub 2014 Nov 12.
J Pharm Sci. 2015.
PMID: 25393841
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A defined subset of adenylyl cyclases is regulated by bicarbonate ion.
Cann MJ, Hammer A, Zhou J, Kanacher T.
Cann MJ, et al. Among authors: kanacher t.
J Biol Chem. 2003 Sep 12;278(37):35033-8. doi: 10.1074/jbc.M303025200. Epub 2003 Jun 26.
J Biol Chem. 2003.
PMID: 12829712
Free article.
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A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch.
Kanacher T, Schultz A, Linder JU, Schultz JE.
Kanacher T, et al.
EMBO J. 2002 Jul 15;21(14):3672-80. doi: 10.1093/emboj/cdf375.
EMBO J. 2002.
PMID: 12110580
Free PMC article.
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