A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction.
Zhong L, Tran T, Baguley TD, Lee SJ, Henke A, To A, Li S, Yu S, Grieco FA, Roland J, Schultz PG, Eizirik DL, Rogers N, Chartterjee AK, Tremblay MS, Shen W.
Zhong L, et al. Among authors: to a.
Br J Pharmacol. 2018 Sep;175(17):3470-3485. doi: 10.1111/bph.14388. Epub 2018 Jul 14.
Br J Pharmacol. 2018.
PMID: 29888783
Free PMC article.
EXPERIMENTAL APPROACH: Diabetogenic media, composed of IL-1beta, IFN-gamma and high glucose, were used to induce mitochondrial stress in rat insulin-producing INS1E cells, and a high-content image-based screen of small molecule modulators of Casp9 pathway was perfor …
EXPERIMENTAL APPROACH: Diabetogenic media, composed of IL-1beta, IFN-gamma and high glucose, were used to induce mitochondrial stress …