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Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation.
Stevens AM, Xiang M, Heppler LN, Tošić I, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA. Stevens AM, et al. Among authors: tosic i. Blood Adv. 2019 Dec 23;3(24):4215-4227. doi: 10.1182/bloodadvances.2019000499. Blood Adv. 2019. PMID: 31856268 Free PMC article.
CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3.
Egusquiaguirre SP, Liu S, Tošić I, Jiang K, Walker SR, Nicolais M, Saw TY, Xiang M, Bartel K, Nelson EA, Frank DA. Egusquiaguirre SP, et al. Among authors: tosic i. Neoplasia. 2020 Jan;22(1):47-59. doi: 10.1016/j.neo.2019.10.002. Epub 2019 Nov 22. Neoplasia. 2020. PMID: 31765941 Free PMC article.
Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors.
Cerulli RA, Shehaj L, Tosic I, Jiang K, Wang J, Frank DA, Kritzer JA. Cerulli RA, et al. Among authors: tosic i. Bioorg Med Chem. 2020 Jun 15;28(12):115542. doi: 10.1016/j.bmc.2020.115542. Epub 2020 May 4. Bioorg Med Chem. 2020. PMID: 32503696 Free PMC article.
Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM).
Lapidot M, Case AE, Larios D, Gandler HI, Meng C, Tošić I, Weisberg EL, Poitras MJ, Gokhale PC, Paweletz CP, Podar K, Salgia R, Saladi SV, Griffin JD, Frank DA, Bueno R, Sattler M. Lapidot M, et al. Among authors: tosic i. Cancers (Basel). 2020 Dec 22;13(1):7. doi: 10.3390/cancers13010007. Cancers (Basel). 2020. PMID: 33374980 Free PMC article.
Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles.
Tošić I, Heppler LN, Egusquiaguirre SP, Boehnke N, Correa S, Costa DF, Moore EAG, Pal S, Richardson DS, Ivanov AR, Haas-Kogan DA, Nomura DK, Hammond PT, Frank DA. Tošić I, et al. Mol Cancer Ther. 2021 Apr;20(4):726-738. doi: 10.1158/1535-7163.MCT-20-0505. Epub 2021 Feb 3. Mol Cancer Ther. 2021. PMID: 33536189 Free PMC article.
The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.
Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, Tošić I, Burton FB, Flamand Y, Walker SR, Yeh JE, Zubarev RA, Gaetani M, Kanarek N, Page BDG, Frank DA. Heppler LN, et al. Among authors: tosic i. J Biol Chem. 2022 Feb;298(2):101531. doi: 10.1016/j.jbc.2021.101531. Epub 2021 Dec 23. J Biol Chem. 2022. PMID: 34953855 Free PMC article.
Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates.
Chen EC, Gandler H, Tošić I, Fell GG, Fiore A, Pozdnyakova O, DeAngelo DJ, Galinsky I, Luskin MR, Wadleigh M, Winer ES, Leonard R, O'Day K, de Jonge A, Neuberg D, Look AT, Stone RM, Frank DA, Garcia JS. Chen EC, et al. Among authors: tosic i. Clin Cancer Res. 2023 Mar 1;29(5):878-887. doi: 10.1158/1078-0432.CCR-22-2540. Clin Cancer Res. 2023. PMID: 36534523 Free PMC article.
Light field otoscope design for 3D in vivo imaging of the middle ear.
Bedard N, Shope T, Hoberman A, Haralam MA, Shaikh N, Kovačević J, Balram N, Tošić I. Bedard N, et al. Among authors: tosic i. Biomed Opt Express. 2016 Dec 14;8(1):260-272. doi: 10.1364/BOE.8.000260. eCollection 2017 Jan 1. Biomed Opt Express. 2016. PMID: 28101416 Free PMC article.
16 results