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Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA. Li N, et al. Among authors: tinsley hn. Mol Cancer Ther. 2013 Sep;12(9):1848-59. doi: 10.1158/1535-7163.MCT-13-0048. Epub 2013 Jun 26. Mol Cancer Ther. 2013. PMID: 23804703 Free PMC article.
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
Whitt JD, Li N, Tinsley HN, Chen X, Zhang W, Li Y, Gary BD, Keeton AB, Xi Y, Abadi AH, Grizzle WE, Piazza GA. Whitt JD, et al. Among authors: tinsley hn. Cancer Prev Res (Phila). 2012 Jun;5(6):822-33. doi: 10.1158/1940-6207.CAPR-11-0559. Epub 2012 May 3. Cancer Prev Res (Phila). 2012. PMID: 22556201 Free PMC article.
27 results