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Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.
Xu J, Grosslight S, Mack KA, Nguyen SC, Clagg K, Lim NK, Timmerman JC, Shen J, White NA, Sirois LE, Han C, Zhang H, Sigman MS, Gosselin F. Xu J, et al. Among authors: timmerman jc. J Am Chem Soc. 2022 Nov 16;144(45):20955-20963. doi: 10.1021/jacs.2c09917. Epub 2022 Nov 3. J Am Chem Soc. 2022. PMID: 36326518
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.
Xu J, Lim NK, Timmerman JC, Shen J, Clagg K, Orcel U, Bigler R, Trachsel E, Meier R, White NA, Burkhard JA, Sirois LE, Tian Q, Angelaud R, Bachmann S, Zhang H, Gosselin F. Xu J, et al. Among authors: timmerman jc. Org Lett. 2023 May 19;25(19):3417-3422. doi: 10.1021/acs.orglett.3c00961. Epub 2023 May 10. Org Lett. 2023. PMID: 37162129
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