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Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles.
Walker A, Schwarz T, Brinkmann-Paulukat J, Wisskirchen K, Menne C, Alizei ES, Kefalakes H, Theissen M, Hoffmann D, Schulze Zur Wiesch J, Maini MK, Cornberg M, Kraft AR, Keitel V, Bock HH, Horn PA, Thimme R, Wedemeyer H, Heinemann FM, Luedde T, Neumann-Haefelin C, Protzer U, Timm J. Walker A, et al. Among authors: timm j. Front Immunol. 2022 Nov 10;13:1045498. doi: 10.3389/fimmu.2022.1045498. eCollection 2022. Front Immunol. 2022. PMID: 36439181 Free PMC article.
Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level.
Neumann-Haefelin C, Frick DN, Wang JJ, Pybus OG, Salloum S, Narula GS, Eckart A, Biezynski A, Eiermann T, Klenerman P, Viazov S, Roggendorf M, Thimme R, Reiser M, Timm J. Neumann-Haefelin C, et al. Among authors: timm j. J Virol. 2008 Apr;82(7):3438-51. doi: 10.1128/JVI.01700-07. Epub 2008 Jan 23. J Virol. 2008. PMID: 18216107 Free PMC article.
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.
Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R, Thimme R. Dazert E, et al. Among authors: timm j. J Clin Invest. 2009 Feb;119(2):376-86. doi: 10.1172/JCI36587. Epub 2009 Jan 12. J Clin Invest. 2009. PMID: 19139562 Free PMC article.
Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope.
Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. Neumann-Haefelin C, et al. Among authors: timm j. Hepatology. 2010 Jan;51(1):54-62. doi: 10.1002/hep.23275. Hepatology. 2010. PMID: 20034048 Free PMC article.
CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins.
Ruhl M, Knuschke T, Schewior K, Glavinic L, Neumann-Haefelin C, Chang DI, Klein M, Heinemann FM, Tenckhoff H, Wiese M, Horn PA, Viazov S, Spengler U, Roggendorf M, Scherbaum N, Nattermann J, Hoffmann D, Timm J; East German HCV Study Group. Ruhl M, et al. Among authors: timm j. Gastroenterology. 2011 Jun;140(7):2064-73. doi: 10.1053/j.gastro.2011.02.060. Epub 2011 Mar 2. Gastroenterology. 2011. PMID: 21376049
346 results