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Withaferin A Analogs That Target the AAA+ Chaperone p97.
Tao S, Tillotson J, Wijeratne EMK, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, Clair JJ, Gunatilaka AAL, Zhang DD, Chapman E. Tao S, et al. Among authors: tillotson j. ACS Chem Biol. 2015 Aug 21;10(8):1916-1924. doi: 10.1021/acschembio.5b00367. Epub 2015 Jun 3. ACS Chem Biol. 2015. PMID: 26006219 Free PMC article.
Arsenic Compromises Both p97 and Proteasome Functions.
Tillotson J, Zerio CJ, Harder B, Ambrose AJ, Jung KS, Kang M, Zhang DD, Chapman E. Tillotson J, et al. Chem Res Toxicol. 2017 Jul 17;30(7):1508-1514. doi: 10.1021/acs.chemrestox.7b00158. Epub 2017 Jul 7. Chem Res Toxicol. 2017. PMID: 28636814 Free PMC article.
Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii.
Wijeratne EM, Gunaherath GM, Chapla VM, Tillotson J, de la Cruz F, Kang M, U'Ren JM, Araujo AR, Arnold AE, Chapman E, Gunatilaka AA. Wijeratne EM, et al. Among authors: tillotson j. J Nat Prod. 2016 Feb 26;79(2):340-52. doi: 10.1021/acs.jnatprod.5b00986. Epub 2016 Jan 26. J Nat Prod. 2016. PMID: 26812276 Free PMC article.
An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol.
Shi T, Wijeratne EMK, Solano C, Ambrose AJ, Ross AB, Norwood C, Orido CK, Grigoryan T, Tillotson J, Kang M, Luo G, Keegan BM, Hu W, Blagg BSJ, Zhang DD, Gunatilaka AAL, Chapman E. Shi T, et al. Among authors: tillotson j. Biochemistry. 2019 Jul 30;58(30):3225-3231. doi: 10.1021/acs.biochem.9b00499. Epub 2019 Jul 18. Biochemistry. 2019. PMID: 31298844 Free PMC article.
ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.
Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. Tillotson J, et al. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4082-4085. doi: 10.1016/j.bmcl.2017.07.045. Epub 2017 Jul 19. Bioorg Med Chem Lett. 2017. PMID: 28757063 Free PMC article.
151 results