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Non-classical ferroptosis inhibition by a small molecule targeting PHB2.
Yang W, Mu B, You J, Tian C, Bin H, Xu Z, Zhang L, Ma R, Wu M, Zhang G, Huang C, Li L, Shao Z, Dai L, Désaubry L, Yang S. Yang W, et al. Among authors: tian c. Nat Commun. 2022 Dec 3;13(1):7473. doi: 10.1038/s41467-022-35294-2. Nat Commun. 2022. PMID: 36463308 Free PMC article.
Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).
Pan S, Zhou Y, Wang Q, Wang Y, Tian C, Wang T, Huang L, Nan J, Li L, Yang S. Pan S, et al. Among authors: tian c. Eur J Med Chem. 2020 Dec 1;207:112703. doi: 10.1016/j.ejmech.2020.112703. Epub 2020 Aug 14. Eur J Med Chem. 2020. PMID: 32871341
Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants.
Pan S, Zhang L, Luo X, Nan J, Yang W, Bin H, Li Y, Huang Q, Wang T, Pan Z, Mu B, Wang F, Tian C, Liu Y, Li L, Yang S. Pan S, et al. Among authors: tian c. J Med Chem. 2022 Feb 10;65(3):2035-2058. doi: 10.1021/acs.jmedchem.1c01597. Epub 2022 Jan 26. J Med Chem. 2022. PMID: 35080890
An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.
Quan BX, Shuai H, Xia AJ, Hou Y, Zeng R, Liu XL, Lin GF, Qiao JX, Li WP, Wang FL, Wang K, Zhou RJ, Yuen TT, Chen MX, Yoon C, Wu M, Zhang SY, Huang C, Wang YF, Yang W, Tian C, Li WM, Wei YQ, Yuen KY, Chan JF, Lei J, Chu H, Yang S. Quan BX, et al. Among authors: tian c. Nat Microbiol. 2022 May;7(5):716-725. doi: 10.1038/s41564-022-01119-7. Epub 2022 Apr 27. Nat Microbiol. 2022. PMID: 35477751
4,525 results