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Therapeutic targeting of hyaluronan in the tumor stroma.
Kultti A, Li X, Jiang P, Thompson CB, Frost GI, Shepard HM. Kultti A, et al. Among authors: thompson cb. Cancers (Basel). 2012 Sep 6;4(3):873-903. doi: 10.3390/cancers4030873. Cancers (Basel). 2012. PMID: 24213471 Free PMC article.
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.
Kultti A, Zhao C, Singha NC, Zimmerman S, Osgood RJ, Symons R, Jiang P, Li X, Thompson CB, Infante JR, Jacobetz MA, Tuveson DA, Frost GI, Shepard HM, Huang Z. Kultti A, et al. Among authors: thompson cb. Biomed Res Int. 2014;2014:817613. doi: 10.1155/2014/817613. Epub 2014 Jul 24. Biomed Res Int. 2014. PMID: 25147816 Free PMC article.
Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression.
Li X, Shepard HM, Cowell JA, Zhao C, Osgood RJ, Rosengren S, Blouw B, Garrovillo SA, Pagel MD, Whatcott CJ, Han H, Von Hoff DD, Taverna DM, LaBarre MJ, Maneval DC, Thompson CB. Li X, et al. Among authors: thompson cb. Clin Cancer Res. 2018 Oct 1;24(19):4798-4807. doi: 10.1158/1078-0432.CCR-17-3284. Epub 2018 Jul 3. Clin Cancer Res. 2018. PMID: 30084839 Free PMC article.
Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation.
Huang Z, Zhao C, Chen Y, Cowell JA, Wei G, Kultti A, Huang L, Thompson CB, Rosengren S, Frost GI, Shepard HM. Huang Z, et al. Among authors: thompson cb. J Immunol. 2014 Jun 1;192(11):5285-95. doi: 10.4049/jimmunol.1303060. Epub 2014 Apr 28. J Immunol. 2014. PMID: 24778442
Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase.
DuFort CC, DelGiorno KE, Carlson MA, Osgood RJ, Zhao C, Huang Z, Thompson CB, Connor RJ, Thanos CD, Scott Brockenbrough J, Provenzano PP, Frost GI, Michael Shepard H, Hingorani SR. DuFort CC, et al. Among authors: thompson cb. Biophys J. 2016 May 10;110(9):2106-19. doi: 10.1016/j.bpj.2016.03.040. Biophys J. 2016. PMID: 27166818 Free PMC article.
Targeting hyaluronan accumulation in the tumor microenvironment.
Li X, Thompson CB. Li X, et al. Among authors: thompson cb. Oncotarget. 2018 Dec 21;9(100):37349-37351. doi: 10.18632/oncotarget.26483. eCollection 2018 Dec 21. Oncotarget. 2018. PMID: 30647836 Free PMC article. No abstract available.
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.
Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, Feig C, Nakagawa T, Caldwell ME, Zecchini HI, Lolkema MP, Jiang P, Kultti A, Thompson CB, Maneval DC, Jodrell DI, Frost GI, Shepard HM, Skepper JN, Tuveson DA. Jacobetz MA, et al. Among authors: thompson cb. Gut. 2013 Jan;62(1):112-20. doi: 10.1136/gutjnl-2012-302529. Epub 2012 Mar 30. Gut. 2013. PMID: 22466618 Free PMC article.
720 results