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Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease.
Tallon C, Bell BJ, Malvankar MM, Deme P, Nogueras-Ortiz C, Eren E, Thomas AG, Hollinger KR, Pal A, Mustapic M, Huang M, Coleman K, Joe TR, Rais R, Haughey NJ, Kapogiannis D, Slusher BS. Tallon C, et al. Among authors: thomas ag. Res Sq [Preprint]. 2023 Jul 18:rs.3.rs-3131295. doi: 10.21203/rs.3.rs-3131295/v1. Res Sq. 2023. PMID: 37502930 Free PMC article. Updated. Preprint.
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, Tsukamoto T, Rojas CJ, Slusher BS, Rabinowitz JD, Dang CV, Riggins GJ. Seltzer MJ, et al. Among authors: thomas ag. Cancer Res. 2010 Nov 15;70(22):8981-7. doi: 10.1158/0008-5472.CAN-10-1666. Epub 2010 Nov 2. Cancer Res. 2010. PMID: 21045145 Free PMC article.
Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice.
Rais R, Thomas AG, Wozniak K, Wu Y, Jaaro-Peled H, Sawa A, Strick CA, Engle SJ, Brandon NJ, Rojas C, Slusher BS, Tsukamoto T. Rais R, et al. Among authors: thomas ag. Drug Metab Dispos. 2012 Nov;40(11):2067-73. doi: 10.1124/dmd.112.046482. Epub 2012 Jul 26. Drug Metab Dispos. 2012. PMID: 22837388 Free PMC article.
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Shukla K, Ferraris DV, Thomas AG, Stathis M, Duvall B, Delahanty G, Alt J, Rais R, Rojas C, Gao P, Xiang Y, Dang CV, Slusher BS, Tsukamoto T. Shukla K, et al. Among authors: thomas ag. J Med Chem. 2012 Dec 13;55(23):10551-63. doi: 10.1021/jm301191p. Epub 2012 Nov 30. J Med Chem. 2012. PMID: 23151085 Free PMC article.
445 results