Thomas AG - Search Results

1

Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.

Duvall B, Zimmermann SC, Gao RD, Thomas AG, Kalčic F, Veeravalli V, Elgogary A, Rais R, Rojas C, Le A, Slusher BS, Tsukamoto T. Duvall B, et al. Among authors: thomas ag. Bioorg Med Chem. 2020 Oct 15;28(20):115698. doi: 10.1016/j.bmc.2020.115698. Epub 2020 Aug 6. Bioorg Med Chem. 2020. PMID: 33069080 Free PMC article.

2

Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.

Thomas AG, Olkowski JL, Vornov JJ, Slusher BS. Thomas AG, et al. Brain Res. 1999 Oct 2;843(1-2):48-52. doi: 10.1016/s0006-8993(99)01879-x. Brain Res. 1999. PMID: 10528109

3

N-Acetylated alpha-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin.

Thomas AG, Vornov JJ, Olkowski JL, Merion AT, Slusher BS. Thomas AG, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):16-22. J Pharmacol Exp Ther. 2000. PMID: 10991955

4

Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE).

Slusher BS, Thomas A, Paul M, Schad CA, Ashby CR Jr. Slusher BS, et al. Synapse. 2001 Jul;41(1):22-8. doi: 10.1002/syn.1056. Synapse. 2001. PMID: 11354010

5

Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation.

Thomas AG, Olkowski JL, Slusher BS. Thomas AG, et al. Eur J Pharmacol. 2001 Aug 24;426(1-2):35-8. doi: 10.1016/s0014-2999(01)01198-0. Eur J Pharmacol. 2001. PMID: 11525768

6

Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta.

Thomas AG, Liu W, Olkowski JL, Tang Z, Lin Q, Lu XC, Slusher BS. Thomas AG, et al. Eur J Pharmacol. 2001 Oct 26;430(1):33-40. doi: 10.1016/s0014-2999(01)01239-0. Eur J Pharmacol. 2001. PMID: 11698060

7

Glutamate carboxypeptidase II inhibition as a novel therapeutic target.

Rojas C, Thomas AG, Majer P, Tsukamoto T, Lu XM, Vornov JJ, Wozniak KM, Slusher BS. Rojas C, et al. Among authors: thomas ag. Adv Exp Med Biol. 2003;524:205-13. doi: 10.1007/0-306-47920-6_25. Adv Exp Med Biol. 2003. PMID: 12675241 Review. No abstract available.

8

Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.

Stoermer D, Liu Q, Hall MR, Flanary JM, Thomas AG, Rojas C, Slusher BS, Tsukamoto T. Stoermer D, et al. Among authors: thomas ag. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2097-100. doi: 10.1016/s0960-894x(03)00407-4. Bioorg Med Chem Lett. 2003. PMID: 12798312

9

NAALADase inhibition protects motor neurons against chronic glutamate toxicity.

Thomas AG, Corse AM, Coccia CF, Bilak MM, Rothstein JD, Slusher BS. Thomas AG, et al. Eur J Pharmacol. 2003 Jun 27;471(3):177-84. doi: 10.1016/s0014-2999(03)01832-6. Eur J Pharmacol. 2003. PMID: 12826236

10

Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.

Ghadge GD, Slusher BS, Bodner A, Canto MD, Wozniak K, Thomas AG, Rojas C, Tsukamoto T, Majer P, Miller RJ, Monti AL, Roos RP. Ghadge GD, et al. Among authors: thomas ag. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9554-9. doi: 10.1073/pnas.1530168100. Epub 2003 Jul 22. Proc Natl Acad Sci U S A. 2003. PMID: 12876198 Free PMC article.

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