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Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes.
Alexandrou C, Al-Aqbi SS, Higgins JA, Boyle W, Karmokar A, Andreadi C, Luo JL, Moore DA, Viskaduraki M, Blades M, Murray GI, Howells LM, Thomas A, Brown K, Cheng PN, Rufini A. Alexandrou C, et al. Among authors: thomas a. Sci Rep. 2018 Aug 14;8(1):12096. doi: 10.1038/s41598-018-30591-7. Sci Rep. 2018. PMID: 30108309 Free PMC article.
Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.
James MI, Iwuji C, Irving G, Karmokar A, Higgins JA, Griffin-Teal N, Thomas A, Greaves P, Cai H, Patel SR, Morgan B, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Howells LM, Brown K. James MI, et al. Among authors: thomas a. Cancer Lett. 2015 Aug 10;364(2):135-41. doi: 10.1016/j.canlet.2015.05.005. Epub 2015 May 12. Cancer Lett. 2015. PMID: 25979230 Free PMC article. Clinical Trial.
Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells.
Alaqbi SS, Burke L, Guterman I, Green C, West K, Palacios-Gallego R, Cai H, Alexandrou C, Myint NNM, Parrott E, Howells LM, Higgins JA, Jones DJL, Singh R, Britton RG, Tufarelli C, Thomas A, Rufini A. Alaqbi SS, et al. Among authors: thomas a. PLoS One. 2022 Feb 7;17(2):e0262364. doi: 10.1371/journal.pone.0262364. eCollection 2022. PLoS One. 2022. PMID: 35130302 Free PMC article.
Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity.
Myint NNM, Verma AM, Fernandez-Garcia D, Sarmah P, Tarpey PS, Al-Aqbi SS, Cai H, Trigg R, West K, Howells LM, Thomas A, Brown K, Guttery DS, Singh B, Pringle HJ, McDermott U, Shaw JA, Rufini A. Myint NNM, et al. Among authors: thomas a. Cell Death Dis. 2018 Aug 30;9(9):894. doi: 10.1038/s41419-018-0934-x. Cell Death Dis. 2018. PMID: 30166531 Free PMC article.
Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial.
Howells LM, Iwuji COO, Irving GRB, Barber S, Walter H, Sidat Z, Griffin-Teall N, Singh R, Foreman N, Patel SR, Morgan B, Steward WP, Gescher A, Thomas AL, Brown K. Howells LM, et al. Among authors: thomas al. J Nutr. 2019 Jul 1;149(7):1133-1139. doi: 10.1093/jn/nxz029. J Nutr. 2019. PMID: 31132111 Free PMC article. Clinical Trial.
9,621 results