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Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy.
Thiele JR, Habersberger J, Braig D, Schmidt Y, Goerendt K, Maurer V, Bannasch H, Scheichl A, Woollard KJ, von Dobschütz E, Kolodgie F, Virmani R, Stark GB, Peter K, Eisenhardt SU. Thiele JR, et al. Circulation. 2014 Jul 1;130(1):35-50. doi: 10.1161/CIRCULATIONAHA.113.007124. Epub 2014 Apr 28. Circulation. 2014. PMID: 24982116
Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites.
Braig D, Nero TL, Koch HG, Kaiser B, Wang X, Thiele JR, Morton CJ, Zeller J, Kiefer J, Potempa LA, Mellett NA, Miles LA, Du XJ, Meikle PJ, Huber-Lang M, Stark GB, Parker MW, Peter K, Eisenhardt SU. Braig D, et al. Among authors: thiele jr. Nat Commun. 2017 Jan 23;8:14188. doi: 10.1038/ncomms14188. Nat Commun. 2017. PMID: 28112148 Free PMC article.
A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury.
Thiele JR, Zeller J, Kiefer J, Braig D, Kreuzaler S, Lenz Y, Potempa LA, Grahammer F, Huber TB, Huber-Lang M, Bannasch H, Stark GB, Peter K, Eisenhardt SU. Thiele JR, et al. Front Immunol. 2018 Apr 16;9:675. doi: 10.3389/fimmu.2018.00675. eCollection 2018. Front Immunol. 2018. PMID: 29713320 Free PMC article.
39 results