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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1.
Park JJ, Thi EP, Carpio VH, Bi Y, Cole AG, Dorsey BD, Fan K, Harasym T, Iott CL, Kadhim S, Kim JH, Lee ACH, Nguyen D, Paratala BS, Qiu R, White A, Lakshminarasimhan D, Leo C, Suto RK, Rijnbrand R, Tang S, Sofia MJ, Moore CB. Park JJ, et al. Among authors: thi ep. Nat Commun. 2021 Feb 22;12(1):1222. doi: 10.1038/s41467-021-21410-1. Nat Commun. 2021. PMID: 33619272 Free PMC article.
The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly.
Cole AG, Kultgen SG, Mani N, Ardzinski A, Fan KY, Thi EP, Dorsey BD, Stever K, Chiu T, Tang S, Daly O, Phelps JR, Harasym T, Olland A, Suto RK, Sofia MJ. Cole AG, et al. Among authors: thi ep. RSC Med Chem. 2022 Jan 19;13(3):343-349. doi: 10.1039/d1md00318f. eCollection 2022 Mar 23. RSC Med Chem. 2022. PMID: 35434625 Free PMC article.
ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection.
Thi EP, Dhillon AP, Ardzinski A, Bidirici-Ertekin L, Cobarrubias KD, Cuconati A, Kondratowicz AS, Kwak K, Li AHL, Miller A, Pasetka C, Pei L, Phelps JR, Snead NM, Wang X, Ye X, Sofia MJ, Lee ACH. Thi EP, et al. ACS Infect Dis. 2019 May 10;5(5):725-737. doi: 10.1021/acsinfecdis.8b00191. Epub 2018 Nov 19. ACS Infect Dis. 2019. PMID: 30403127
Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB-506 from Phase 1 studies in healthy subjects and those with hepatitis B.
Yuen MF, Berliba E, Sukeepaisarnjaroen W, Ahn SH, Tanwandee T, Lim YS, Kim YJ, Poovorawan K, Tangkijvanich P, Schwabe C, Eley T, Brown J, Lee ACH, Thi EP, Paratala B, Mani N, Sofia MJ, Picchio G, Sims KD, Gane EJ. Yuen MF, et al. Among authors: thi ep. Hepatol Commun. 2022 Dec;6(12):3457-3472. doi: 10.1002/hep4.2095. Epub 2022 Oct 4. Hepatol Commun. 2022. PMID: 36194181 Free PMC article. Clinical Trial.
Ligand conjugate SAR and enhanced delivery in NHP.
Holland RJ, Lam K, Ye X, Martin AD, Wood MC, Palmer L, Fraser D, McClintock K, Majeski S, Jarosz A, Lee ACH, Thi EP, Judge A, Heyes J. Holland RJ, et al. Among authors: thi ep. Mol Ther. 2021 Oct 6;29(10):2910-2919. doi: 10.1016/j.ymthe.2021.06.002. Epub 2021 Jun 4. Mol Ther. 2021. PMID: 34091052 Free PMC article.
siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease.
Thi EP, Mire CE, Lee AC, Geisbert JB, Ursic-Bedoya R, Agans KN, Robbins M, Deer DJ, Cross RW, Kondratowicz AS, Fenton KA, MacLachlan I, Geisbert TW. Thi EP, et al. J Clin Invest. 2017 Dec 1;127(12):4437-4448. doi: 10.1172/JCI96185. Epub 2017 Nov 6. J Clin Invest. 2017. PMID: 29106386 Free PMC article.
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