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Adhesion-mediated mechanosignaling forces mitohormesis.
Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM. Tharp KM, et al. Cell Metab. 2021 Jul 6;33(7):1322-1341.e13. doi: 10.1016/j.cmet.2021.04.017. Epub 2021 May 20. Cell Metab. 2021. PMID: 34019840 Free PMC article.
The Sense of Smell Impacts Metabolic Health and Obesity.
Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A. Riera CE, et al. Cell Metab. 2017 Jul 5;26(1):198-211.e5. doi: 10.1016/j.cmet.2017.06.015. Cell Metab. 2017. PMID: 28683287 Free article.
Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues.
Tharp KM, Kang MS, Timblin GA, Dempersmier J, Dempsey GE, Zushin PH, Benavides J, Choi C, Li CX, Jha AK, Kajimura S, Healy KE, Sul HS, Saijo K, Kumar S, Stahl A. Tharp KM, et al. Cell Metab. 2018 Mar 6;27(3):602-615.e4. doi: 10.1016/j.cmet.2018.02.005. Cell Metab. 2018. PMID: 29514068 Free PMC article.
Modeling Tissue Polarity in Context.
Tharp KM, Weaver VM. Tharp KM, et al. J Mol Biol. 2018 Sep 28;430(19):3613-3628. doi: 10.1016/j.jmb.2018.07.015. Epub 2018 Jul 25. J Mol Biol. 2018. PMID: 30055167 Free PMC article. Review.
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance.
Timblin GA, Tharp KM, Ford B, Winchester JM, Wang J, Zhu S, Khan RI, Louie SK, Iavarone AT, Ten Hoeve J, Nomura DK, Stahl A, Saijo K. Timblin GA, et al. Among authors: tharp km. Nat Metab. 2021 May;3(5):618-635. doi: 10.1038/s42255-021-00392-w. Epub 2021 May 20. Nat Metab. 2021. PMID: 34031590 Free PMC article.
Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.
Moehle EA, Higuchi-Sanabria R, Tsui CK, Homentcovschi S, Tharp KM, Zhang H, Chi H, Joe L, de Los Rios Rogers M, Sahay A, Kelet N, Benitez C, Bar-Ziv R, Garcia G, Shen K, Frankino PA, Schinzel RT, Shalem O, Dillin A. Moehle EA, et al. Among authors: tharp km. Sci Adv. 2021 Oct 29;7(44):eabj6818. doi: 10.1126/sciadv.abj6818. Epub 2021 Oct 29. Sci Adv. 2021. PMID: 34714674 Free PMC article.
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.
Ferguson ID, Lin YT, Lam C, Shao H, Tharp KM, Hale M, Kasap C, Mariano MC, Kishishita A, Patiño Escobar B, Mandal K, Steri V, Wang D, Phojanakong P, Tuomivaara ST, Hann B, Driessen C, Van Ness B, Gestwicki JE, Wiita AP. Ferguson ID, et al. Among authors: tharp km. Cell Chem Biol. 2022 Aug 18;29(8):1288-1302.e7. doi: 10.1016/j.chembiol.2022.06.010. Epub 2022 Jul 18. Cell Chem Biol. 2022. PMID: 35853457 Free PMC article.
30 results