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Ligand-induced conformational changes in a SMALP-encapsulated GPCR.
Routledge SJ, Jamshad M, Little HA, Lin YP, Simms J, Thakker A, Spickett CM, Bill RM, Dafforn TR, Poyner DR, Wheatley M. Routledge SJ, et al. Among authors: thakker a. Biochim Biophys Acta Biomembr. 2020 Jun 1;1862(6):183235. doi: 10.1016/j.bbamem.2020.183235. Epub 2020 Feb 29. Biochim Biophys Acta Biomembr. 2020. PMID: 32126232 Free PMC article.
Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice.
Nasteska D, Cuozzo F, Viloria K, Johnson EM, Thakker A, Bany Bakar R, Westbrook RL, Barlow JP, Hoang M, Joseph JW, Lavery GG, Akerman I, Cantley J, Hodson L, Tennant DA, Hodson DJ. Nasteska D, et al. Among authors: thakker a. JCI Insight. 2021 Aug 23;6(16):e140288. doi: 10.1172/jci.insight.140288. JCI Insight. 2021. PMID: 34264866 Free PMC article.
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA. Hollinshead KER, et al. Among authors: thakker a. Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084. Cell Rep. 2018. PMID: 29562167 Free PMC article.
Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD + depletion.
Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG. Oakey LA, et al. Among authors: thakker a. Wellcome Open Res. 2019 Sep 17;3:147. doi: 10.12688/wellcomeopenres.14898.2. eCollection 2018. Wellcome Open Res. 2019. PMID: 30607371 Free PMC article.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Goncalves J, Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J. Goncalves J, et al. Among authors: thakker a. Cancer Res. 2021 Jul 1;81(13):3480-3494. doi: 10.1158/0008-5472.CAN-20-2936. Epub 2021 Jun 14. Cancer Res. 2021. PMID: 34127497 Free article.
47 results