Thabault L - Search Results

1

Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides.

Thabault L, Brisson L, Brustenga C, Martinez Gache SA, Prévost JRC, Kozlova A, Spillier Q, Liberelle M, Benyahia Z, Messens J, Copetti T, Sonveaux P, Frédérick R. Thabault L, et al. J Med Chem. 2020 May 14;63(9):4628-4643. doi: 10.1021/acs.jmedchem.9b01955. Epub 2020 Apr 15. J Med Chem. 2020. PMID: 32250117

2

Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase.

Kozlova A, Thabault L, Liberelle M, Klaessens S, Prévost JRC, Mathieu C, Pilotte L, Stroobant V, Van den Eynde B, Frédérick R. Kozlova A, et al. Among authors: thabault l. J Med Chem. 2021 Aug 12;64(15):10967-10980. doi: 10.1021/acs.jmedchem.1c00323. Epub 2021 Aug 2. J Med Chem. 2021. PMID: 34338527

3

Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides.

Thabault L, Liberelle M, Koruza K, Yildiz E, Joudiou N, Messens J, Brisson L, Wouters J, Sonveaux P, Frédérick R. Thabault L, et al. J Biol Chem. 2021 Jan-Jun;296:100422. doi: 10.1016/j.jbc.2021.100422. Epub 2021 Feb 17. J Biol Chem. 2021. PMID: 33607109 Free PMC article.

4

Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase.

Kozlova A, Thabault L, Dauguet N, Deskeuvre M, Stroobant V, Pilotte L, Liberelle M, Van den Eynde B, Frédérick R. Kozlova A, et al. Among authors: thabault l. Eur J Med Chem. 2022 Jan 5;227:113892. doi: 10.1016/j.ejmech.2021.113892. Epub 2021 Oct 7. Eur J Med Chem. 2022. PMID: 34678572

5

Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade.

Thabault L, Brustenga C, Savoyen P, Van Gysel M, Wouters J, Sonveaux P, Frédérick R, Liberelle M. Thabault L, et al. Eur J Med Chem. 2022 Feb 15;230:114102. doi: 10.1016/j.ejmech.2022.114102. Epub 2022 Jan 12. Eur J Med Chem. 2022. PMID: 35074589

6

Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments.

Spillier Q, Ravez S, Dochain S, Vertommen D, Thabault L, Feron O, Frédérick R. Spillier Q, et al. Among authors: thabault l. Molecules. 2021 Jan 18;26(2):477. doi: 10.3390/molecules26020477. Molecules. 2021. PMID: 33477510 Free PMC article.

7

Targeting protein self-association in drug design.

Thabault L, Liberelle M, Frédérick R. Thabault L, et al. Drug Discov Today. 2021 May;26(5):1148-1163. doi: 10.1016/j.drudis.2021.01.028. Epub 2021 Feb 3. Drug Discov Today. 2021. PMID: 33548462 Review.

8

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.

Ameryckx A, Thabault L, Pochet L, Leimanis S, Poupaert JH, Wouters J, Joris B, Van Bambeke F, Frédérick R. Ameryckx A, et al. Among authors: thabault l. Eur J Med Chem. 2018 Nov 5;159:324-338. doi: 10.1016/j.ejmech.2018.09.067. Epub 2018 Sep 28. Eur J Med Chem. 2018. PMID: 30300845

9

Correction to "Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase".

Kozlova A, Thabault L, Liberelle M, Klaessens S, Prévost JRC, Mathieu C, Pilotte L, Stroobant V, Van den Eynde B, Frédérick R. Kozlova A, et al. Among authors: thabault l. J Med Chem. 2021 Sep 9;64(17):13096. doi: 10.1021/acs.jmedchem.1c01455. Epub 2021 Aug 26. J Med Chem. 2021. PMID: 34436896 No abstract available.

10

Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells.

Zampieri LX, Sboarina M, Cacace A, Grasso D, Thabault L, Hamelin L, Vazeille T, Dumon E, Rossignol R, Frédérick R, Sonveaux E, Lefranc F, Sonveaux P. Zampieri LX, et al. Among authors: thabault l. Int J Mol Sci. 2021 Nov 3;22(21):11938. doi: 10.3390/ijms222111938. Int J Mol Sci. 2021. PMID: 34769368 Free PMC article.

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