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Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction.
Mir S, Golden BDO, Griess BJ, Vengoji R, Tom E, Kosmacek EA, Oberley-Deegan RE, Talmon GA, Band V, Teoh-Fitzgerald ML. Mir S, et al. Among authors: teoh fitzgerald ml. Breast Cancer Res. 2022 Jul 14;24(1):48. doi: 10.1186/s13058-022-01548-6. Breast Cancer Res. 2022. PMID: 35836253 Free PMC article.
Extracellular superoxide dismutase and its role in cancer.
Griess B, Tom E, Domann F, Teoh-Fitzgerald M. Griess B, et al. Free Radic Biol Med. 2017 Nov;112:464-479. doi: 10.1016/j.freeradbiomed.2017.08.013. Epub 2017 Aug 24. Free Radic Biol Med. 2017. PMID: 28842347 Free PMC article. Review.
SIRT1-NOX4 signaling axis regulates cancer cachexia.
Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. Dasgupta A, et al. J Exp Med. 2020 Jul 6;217(7):e20190745. doi: 10.1084/jem.20190745. J Exp Med. 2020. PMID: 32441762 Free PMC article.
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