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Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED. Patel SJ, et al. Among authors: tchernof a. Sci Transl Med. 2022 Mar 23;14(637):eabh3831. doi: 10.1126/scitranslmed.abh3831. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320000 Free PMC article.
Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity.
Grenier-Larouche T, Coulter Kwee L, Deleye Y, Leon-Mimila P, Walejko JM, McGarrah RW, Marceau S, Trahan S, Racine C, Carpentier AC, Lusis AJ, Ilkayeva O, Vohl MC, Huertas-Vazquez A, Tchernof A, Shah SH, Newgard CB, White PJ. Grenier-Larouche T, et al. Among authors: tchernof a. JCI Insight. 2022 Aug 8;7(15):e159204. doi: 10.1172/jci.insight.159204. JCI Insight. 2022. PMID: 35797133 Free PMC article.
Bariatric Surgery Rapidly Decreases Cardiac Dietary Fatty Acid Partitioning and Hepatic Insulin Resistance Through Increased Intra-abdominal Adipose Tissue Storage and Reduced Spillover in Type 2 Diabetes.
Carreau AM, Noll C, Blondin DP, Frisch F, Nadeau M, Pelletier M, Phoenix S, Cunnane SC, Guérin B, Turcotte EE, Lebel S, Biertho L, Tchernof A, Carpentier AC. Carreau AM, et al. Among authors: tchernof a. Diabetes. 2020 Apr;69(4):567-577. doi: 10.2337/db19-0773. Epub 2020 Jan 8. Diabetes. 2020. PMID: 31915151
Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease.
Ghodsian N, Abner E, Emdin CA, Gobeil É, Taba N, Haas ME, Perrot N, Manikpurage HD, Gagnon É, Bourgault J, St-Amand A, Couture C, Mitchell PL, Bossé Y, Mathieu P, Vohl MC, Tchernof A, Thériault S, Khera AV, Esko T, Arsenault BJ. Ghodsian N, et al. Among authors: tchernof a. Cell Rep Med. 2021 Nov 3;2(11):100437. doi: 10.1016/j.xcrm.2021.100437. eCollection 2021 Nov 16. Cell Rep Med. 2021. PMID: 34841290 Free PMC article.
Neck circumference is a better correlate of insulin resistance markers than other standard anthropometric indices in patients presenting severe obesity.
Scovronec A, Provencher A, Iceta S, Pelletier M, Leblanc V, Nadeau M, Simard S, Biertho L, Richard D, Tchernof A, Michaud A. Scovronec A, et al. Among authors: tchernof a. Obes Res Clin Pract. 2022 Jul-Aug;16(4):307-313. doi: 10.1016/j.orcp.2022.07.005. Epub 2022 Jul 22. Obes Res Clin Pract. 2022. PMID: 35879202
IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery.
Faramia J, Hao Z, Mumphrey MB, Townsend RL, Miard S, Carreau AM, Nadeau M, Frisch F, Baraboi ED, Grenier-Larouche T, Noll C, Li M, Biertho L, Marceau S, Hould FS, Lebel S, Morrison CD, Münzberg H, Richard D, Carpentier AC, Tchernof A, Berthoud HR, Picard F. Faramia J, et al. Among authors: tchernof a. Cell Rep Med. 2021 Apr 20;2(4):100248. doi: 10.1016/j.xcrm.2021.100248. eCollection 2021 Apr 20. Cell Rep Med. 2021. PMID: 33948578 Free PMC article.
312 results