Taylor TJ - Search Results

1

On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics.

Kalgutkar AS, Dalvie DK, O'Donnell JP, Taylor TJ, Sahakian DC. Kalgutkar AS, et al. Among authors: taylor tj. Curr Drug Metab. 2002 Aug;3(4):379-424. doi: 10.2174/1389200023337360. Curr Drug Metab. 2002. PMID: 12093357 Review.

2

Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway.

Kalgutkar AS, Taylor TJ, Venkatakrishnan K, Isin EM. Kalgutkar AS, et al. Among authors: taylor tj. Drug Metab Dispos. 2003 Mar;31(3):243-9. doi: 10.1124/dmd.31.3.243. Drug Metab Dispos. 2003. PMID: 12584149

3

Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6.

Kalgutkar AS, Zhou S, Fahmi OA, Taylor TJ. Kalgutkar AS, et al. Among authors: taylor tj. Drug Metab Dispos. 2003 May;31(5):596-605. doi: 10.1124/dmd.31.5.596. Drug Metab Dispos. 2003. PMID: 12695348

4

Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors.

Kalgutkar AS, Dalvie DK, Castagnoli N Jr, Taylor TJ. Kalgutkar AS, et al. Among authors: taylor tj. Chem Res Toxicol. 2001 Sep;14(9):1139-62. doi: 10.1021/tx010073b. Chem Res Toxicol. 2001. PMID: 11559028 Review. No abstract available.

5

Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.

Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA. Kalgutkar AS, et al. Among authors: taylor tj. Biopharm Drug Dispos. 2006 Nov;27(8):371-86. doi: 10.1002/bdd.520. Biopharm Drug Dispos. 2006. PMID: 16944451

6

Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species.

Kalgutkar AS, Choo E, Taylor TJ, Marfat A. Kalgutkar AS, et al. Among authors: taylor tj. Xenobiotica. 2004 Aug;34(8):755-70. doi: 10.1080/00498250400005682. Xenobiotica. 2004. PMID: 15690763

7

Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.

McClure KF, Letavic MA, Kalgutkar AS, Gabel CA, Audoly L, Barberia JT, Braganza JF, Carter D, Carty TJ, Cortina SR, Dombroski MA, Donahue KM, Elliott NC, Gibbons CP, Jordan CK, Kuperman AV, Labasi JM, Laliberte RE, McCoy JM, Naiman BM, Nelson KL, Nguyen HT, Peese KM, Sweeney FJ, Taylor TJ, Trebino CE, Abramov YA, Laird ER, Volberg WA, Zhou J, Bach J, Lombardo F. McClure KF, et al. Among authors: taylor tj. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4339-44. doi: 10.1016/j.bmcl.2006.05.056. Epub 2006 Jun 12. Bioorg Med Chem Lett. 2006. PMID: 16759861

8

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

Duplantier AJ, Dombroski MA, Subramanyam C, Beaulieu AM, Chang SP, Gabel CA, Jordan C, Kalgutkar AS, Kraus KG, Labasi JM, Mussari C, Perregaux DG, Shepard R, Taylor TJ, Trevena KA, Whitney-Pickett C, Yoon K. Duplantier AJ, et al. Among authors: taylor tj. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11. doi: 10.1016/j.bmcl.2011.04.077. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21565499

9

Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers.

Taylor TJ, Diringer K, Russell T, Venkatakrishnan K, Wilner K, Crownover PH, Benincosa LJ, Gibbs MA. Taylor TJ, et al. Clin Pharmacokinet. 2006;45(10):989-1001. doi: 10.2165/00003088-200645100-00003. Clin Pharmacokinet. 2006. PMID: 16984212 Clinical Trial.

10

Perioperative nutritional status thought to be important, but poorly understood.

Firoozabadi R, Taylor TJ, Fernando N, Hsu JR, Stinner D, Obremskey W, Castillo RC; Major Extremity Trauma Research Consortium (METRC). Firoozabadi R, et al. Among authors: taylor tj. Eur J Orthop Surg Traumatol. 2024 Mar 3. doi: 10.1007/s00590-024-03858-1. Online ahead of print. Eur J Orthop Surg Traumatol. 2024. PMID: 38431894

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

106 results

Search Page