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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
Beaudoin JJ, Clemens L, Miedel MT, Gough A, Zaidi F, Ramamoorthy P, Wong KE, Sarangarajan R, Battista C, Shoda LKM, Siler SQ, Taylor DL, Howell BA, Vernetti LA, Yang K. Beaudoin JJ, et al. Among authors: taylor dl. Int J Mol Sci. 2023 Jun 2;24(11):9692. doi: 10.3390/ijms24119692. Int J Mol Sci. 2023. PMID: 37298645 Free PMC article.
Biofabrication of synthetic human liver tissue with advanced programmable functions.
Florentino RM, Morita K, Haep N, Motomura T, Diaz-Aragon R, Faccioli LAP, Collin de l'Hortet A, Cetin Z, Frau C, Vernetti L, Amler AK, Thomas A, Lam T, Kloke L, Takeishi K, Taylor DL, Fox IJ, Soto-Gutierrez A. Florentino RM, et al. Among authors: taylor dl. iScience. 2022 Nov 4;25(12):105503. doi: 10.1016/j.isci.2022.105503. eCollection 2022 Dec 22. iScience. 2022. PMID: 36404924 Free PMC article.
Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants.
Faccioli LAP, Cetin Z, Kocas-Kilicarslan ZN, Ortiz K, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Wang Z, Xia M, Miedel MT, Taylor DL, Behari J, Ostrowska A, Constantine R, Li A, Soto-Gutierrez A. Faccioli LAP, et al. Among authors: taylor dl. Int J Mol Sci. 2023 Aug 29;24(17):13406. doi: 10.3390/ijms241713406. Int J Mol Sci. 2023. PMID: 37686209 Free PMC article.
Polymorphisms Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease Influence the Progression of End-Stage Liver Disease.
Kocas-Kilicarslan ZN, Cetin Z, Faccioli LAP, Motomura T, Amirneni S, Diaz-Aragon R, Florentino RM, Sun Y, Pla-Palacin I, Xia M, Miedel MT, Kurihara T, Hu Z, Ostrowska A, Wang Z, Constantine R, Li A, Taylor DL, Behari J, Soto-Gutierrez A, Tafaleng EN. Kocas-Kilicarslan ZN, et al. Among authors: taylor dl. Gastro Hep Adv. 2024;3(1):67-77. doi: 10.1016/j.gastha.2023.09.011. Epub 2023 Oct 5. Gastro Hep Adv. 2024. PMID: 38292457 Free PMC article.
Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy.
Xia M, Varmazyad M, Palacin IP, Gavlock DC, Debiasio R, LaRocca G, Reese C, Florentino R, Faccioli LAP, Brown JA, Vernetti LA, Schurdak ME, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL, Miedel M. Xia M, et al. Among authors: taylor dl. bioRxiv [Preprint]. 2024 May 7:2024.04.22.590608. doi: 10.1101/2024.04.22.590608. bioRxiv. 2024. PMID: 38712213 Free PMC article. Preprint.
Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.
Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, Fondevila C, Stärkel P, Dubuquoy L, Louvet A, Odena G, Gomez JL, Aragon T, Altamirano J, Caballeria J, Jurczak MJ, Taylor DL, Berasain C, Wahlestedt C, Monga SP, Morgan MY, Sancho-Bru P, Mathurin P, Furuya S, Lackner C, Rusyn I, Shah VH, Thursz MR, Mann J, Avila MA, Bataller R. Argemi J, et al. Among authors: taylor dl. Nat Commun. 2023 Feb 10;14(1):757. doi: 10.1038/s41467-023-36548-3. Nat Commun. 2023. PMID: 36765087 Free PMC article. No abstract available.
A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
Aleman J, Ravikumar K, Wiegand C, Schurdak ME, Vernetti L, Gavlock D, Reese C, DeBiasio R, LaRocca G, Angarita YD, Gough A, Soto-Gutierrez A, Behari J, Yechoor V, Miedel MT, Stern AM, Banerjee I, Taylor DL. Aleman J, et al. Among authors: taylor dl. bioRxiv [Preprint]. 2024 Apr 30:2024.04.22.590598. doi: 10.1101/2024.04.22.590598. bioRxiv. 2024. PMID: 38712135 Free PMC article. Preprint.
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Nok Chong AC, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhong A, Bonnycastle LL, Zhou T, Chen S, Collins FS. Xue D, et al. Among authors: taylor dl. Cell Metab. 2023 Nov 7;35(11):1897-1914.e11. doi: 10.1016/j.cmet.2023.09.013. Epub 2023 Oct 18. Cell Metab. 2023. PMID: 37858332 Free article.
487 results