Tate EW - Search Results

1

High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.

Dian C, Pérez-Dorado I, Rivière F, Asensio T, Legrand P, Ritzefeld M, Shen M, Cota E, Meinnel T, Tate EW, Giglione C. Dian C, et al. Among authors: tate ew. Nat Commun. 2020 Feb 28;11(1):1132. doi: 10.1038/s41467-020-14847-3. Nat Commun. 2020. PMID: 32111831 Free PMC article.

2

Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.

Thomas JC, Green JL, Howson RI, Simpson P, Moss DK, Martin SR, Holder AA, Cota E, Tate EW. Thomas JC, et al. Among authors: tate ew. Mol Biosyst. 2010 Mar;6(3):494-8. doi: 10.1039/b922093c. Epub 2010 Jan 27. Mol Biosyst. 2010. PMID: 20174678

3

A fluorescence-based assay for N-myristoyltransferase activity.

Goncalves V, Brannigan JA, Thinon E, Olaleye TO, Serwa R, Lanzarone S, Wilkinson AJ, Tate EW, Leatherbarrow RJ. Goncalves V, et al. Among authors: tate ew. Anal Biochem. 2012 Feb 1;421(1):342-4. doi: 10.1016/j.ab.2011.10.013. Epub 2011 Oct 14. Anal Biochem. 2012. PMID: 22051857 Free PMC article.

4

Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry.

Heal WP, Wright MH, Thinon E, Tate EW. Heal WP, et al. Among authors: tate ew. Nat Protoc. 2011 Dec 22;7(1):105-17. doi: 10.1038/nprot.2011.425. Nat Protoc. 2011. PMID: 22193303 Free article.

5

Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.

Goncalves V, Brannigan JA, Whalley D, Ansell KH, Saxty B, Holder AA, Wilkinson AJ, Tate EW, Leatherbarrow RJ. Goncalves V, et al. Among authors: tate ew. J Med Chem. 2012 Apr 12;55(7):3578-82. doi: 10.1021/jm300040p. Epub 2012 Apr 3. J Med Chem. 2012. PMID: 22439843 Free PMC article.

6

Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA.

Douse CH, Green JL, Salgado PS, Simpson PJ, Thomas JC, Langsley G, Holder AA, Tate EW, Cota E. Douse CH, et al. Among authors: tate ew. J Biol Chem. 2012 Oct 26;287(44):36968-77. doi: 10.1074/jbc.M112.379842. Epub 2012 Aug 29. J Biol Chem. 2012. PMID: 22932904 Free PMC article.

7

Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Yu Z, et al. Among authors: tate ew. J Med Chem. 2012 Oct 25;55(20):8879-90. doi: 10.1021/jm301160h. Epub 2012 Oct 15. J Med Chem. 2012. PMID: 23035716 Free PMC article.

8

Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.

Rackham MD, Brannigan JA, Moss DK, Yu Z, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Rackham MD, et al. Among authors: tate ew. J Med Chem. 2013 Jan 10;56(1):371-5. doi: 10.1021/jm301474t. Epub 2012 Dec 17. J Med Chem. 2013. PMID: 23170970 Free PMC article.

9

N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis.

Tate EW, Bell AS, Rackham MD, Wright MH. Tate EW, et al. Parasitology. 2014 Jan;141(1):37-49. doi: 10.1017/S0031182013000450. Epub 2013 Apr 24. Parasitology. 2014. PMID: 23611109 Free article. Review.

10

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.

Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Wright MH, et al. Among authors: tate ew. Nat Chem. 2014 Feb;6(2):112-21. doi: 10.1038/nchem.1830. Epub 2013 Dec 22. Nat Chem. 2014. PMID: 24451586 Free PMC article.

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