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Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2 N protein.
Nakayama EE, Kubota-Koketsu R, Sasaki T, Suzuki K, Uno K, Shimizu J, Okamoto T, Matsumoto H, Matsuura H, Hashimoto S, Tanaka T, Harada H, Tomita M, Kaneko M, Yoshizaki K, Shioda T. Nakayama EE, et al. Among authors: tanaka t. Sci Rep. 2022 May 16;12(1):8108. doi: 10.1038/s41598-022-12252-y. Sci Rep. 2022. PMID: 35577892 Free PMC article.
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome.
Kang S, Tanaka T, Inoue H, Ono C, Hashimoto S, Kioi Y, Matsumoto H, Matsuura H, Matsubara T, Shimizu K, Ogura H, Matsuura Y, Kishimoto T. Kang S, et al. Among authors: tanaka t. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22351-22356. doi: 10.1073/pnas.2010229117. Epub 2020 Aug 21. Proc Natl Acad Sci U S A. 2020. PMID: 32826331 Free PMC article.
Reply to Cheng et al.: COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling.
Kang S, Tanaka T, Inoue H, Ono C, Hashimoto S, Kioi Y, Matsumoto H, Matsuura H, Matsubara T, Shimizu K, Ogura H, Matsuura Y, Kishimoto T. Kang S, et al. Among authors: tanaka t. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2105040118. doi: 10.1073/pnas.2105040118. Proc Natl Acad Sci U S A. 2021. PMID: 33972413 Free PMC article. No abstract available.
Prompt Reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-19.
Hashimoto S, Yoshizaki K, Uno K, Kitajima H, Arai T, Tamura Y, Morishita H, Matsuoka H, Han Y, Minamoto S, Hirashima T, Yamada T, Kashiwa Y, Kameda M, Yamaguchi S, Tsuchihashi Y, Iwahashi M, Nakayama E, Shioda T, Nagai T, Tanaka T. Hashimoto S, et al. Among authors: tanaka t. Front Med (Lausanne). 2021 Sep 23;8:734838. doi: 10.3389/fmed.2021.734838. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34631752 Free PMC article.
Clinical Importance of a Cytokine Network in Major Burns.
Matsuura H, Matsumoto H, Osuka A, Ogura H, Shimizu K, Kang S, Tanaka T, Ueyama M, Shimazu T. Matsuura H, et al. Among authors: tanaka t. Shock. 2019 Feb;51(2):185-193. doi: 10.1097/SHK.0000000000001152. Shock. 2019. PMID: 29621119 Clinical Trial.
Clinical COVID-19 diagnostic methods: Comparison of reverse transcription loop-mediated isothermal amplification (RT-LAMP) and quantitative RT-PCR (qRT-PCR).
Kitajima H, Tamura Y, Yoshida H, Kinoshita H, Katsuta H, Matsui C, Matsushita A, Arai T, Hashimoto S, Iuchi A, Hirashima T, Morishita H, Matsuoka H, Tanaka T, Nagai T. Kitajima H, et al. Among authors: tanaka t. J Clin Virol. 2021 Jun;139:104813. doi: 10.1016/j.jcv.2021.104813. Epub 2021 Mar 26. J Clin Virol. 2021. PMID: 33848785 Free PMC article.
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