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CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Kidani Y, Nogami W, Yasumizu Y, Kawashima A, Tanaka A, Sonoda Y, Tona Y, Nashiki K, Matsumoto R, Hagiwara M, Osaki M, Dohi K, Kanazawa T, Ueyama A, Yoshikawa M, Yoshida T, Matsumoto M, Hojo K, Shinonome S, Yoshida H, Hirata M, Haruna M, Nakamura Y, Motooka D, Okuzaki D, Sugiyama Y, Kinoshita M, Okuno T, Kato T, Hatano K, Uemura M, Imamura R, Yokoi K, Tanemura A, Shintani Y, Kimura T, Nonomura N, Wada H, Mori M, Doki Y, Ohkura N, Sakaguchi S. Kidani Y, et al. Among authors: tanaka a. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2114282119. doi: 10.1073/pnas.2114282119. Proc Natl Acad Sci U S A. 2022. PMID: 35140181 Free PMC article.
Regulatory T cells in cancer immunotherapy.
Tanaka A, Sakaguchi S. Tanaka A, et al. Cell Res. 2017 Jan;27(1):109-118. doi: 10.1038/cr.2016.151. Epub 2016 Dec 20. Cell Res. 2017. PMID: 27995907 Free PMC article. Review.
Targeting Treg cells in cancer immunotherapy.
Tanaka A, Sakaguchi S. Tanaka A, et al. Eur J Immunol. 2019 Aug;49(8):1140-1146. doi: 10.1002/eji.201847659. Epub 2019 Jul 5. Eur J Immunol. 2019. PMID: 31257581 Free article. Review.
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.
Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S. Ohkura N, et al. Among authors: tanaka a, tanaka y. Immunity. 2012 Nov 16;37(5):785-99. doi: 10.1016/j.immuni.2012.09.010. Epub 2012 Nov 1. Immunity. 2012. PMID: 23123060 Free article.
Immunology. Early life Aire.
Tanaka A, Sakaguchi S. Tanaka A, et al. Science. 2015 May 1;348(6234):506-7. doi: 10.1126/science.aab2998. Epub 2015 Apr 30. Science. 2015. PMID: 25931543 No abstract available.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
Kamada T, Togashi Y, Tay C, Ha D, Sasaki A, Nakamura Y, Sato E, Fukuoka S, Tada Y, Tanaka A, Morikawa H, Kawazoe A, Kinoshita T, Shitara K, Sakaguchi S, Nishikawa H. Kamada T, et al. Among authors: tanaka a. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9999-10008. doi: 10.1073/pnas.1822001116. Epub 2019 Apr 26. Proc Natl Acad Sci U S A. 2019. PMID: 31028147 Free PMC article.
Regulatory T Cells and Human Disease.
Sakaguchi S, Mikami N, Wing JB, Tanaka A, Ichiyama K, Ohkura N. Sakaguchi S, et al. Among authors: tanaka a. Annu Rev Immunol. 2020 Apr 26;38:541-566. doi: 10.1146/annurev-immunol-042718-041717. Epub 2020 Feb 4. Annu Rev Immunol. 2020. PMID: 32017635 Review.
6,205 results