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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Bioorg Med Chem Lett. 2012 Dec 15;22(24):7653-8. doi: 10.1016/j.bmcl.2012.10.007. Epub 2012 Oct 16.
Bioorg Med Chem Lett. 2012.
PMID: 23127890
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).
Takeuchi CS, Kim BG, Blazey CM, Ma S, Johnson HW, Anand NK, Arcalas A, Baik TG, Buhr CA, Cannoy J, Epshteyn S, Joshi A, Lara K, Lee MS, Wang L, Leahy JW, Nuss JM, Aay N, Aoyama R, Foster P, Lee J, Lehoux I, Munagala N, Plonowski A, Rajan S, Woolfrey J, Yamaguchi K, Lamb P, Miller N.
Takeuchi CS, et al.
J Med Chem. 2013 Mar 28;56(6):2218-34. doi: 10.1021/jm3007933. Epub 2013 Mar 7.
J Med Chem. 2013.
PMID: 23394126
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Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption.
Violette SM, Guan W, Bartlett C, Smith JA, Bardelay C, Antoine E, Rickles RJ, Mandine E, van Schravendijk MR, Adams SE, Lynch BA, Shakespeare WC, Yang M, Jacobsen VA, Takeuchi CS, Macek KJ, Bohacek RS, Dalgarno DC, Weigele M, Lesuisse D, Sawyer TK, Baron R.
Violette SM, et al. Among authors: takeuchi cs.
Bone. 2001 Jan;28(1):54-64. doi: 10.1016/s8756-3282(00)00427-0.
Bone. 2001.
PMID: 11165943
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Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.
Ojima I, Slater JC, Kuduk SD, Takeuchi CS, Gimi RH, Sun CM, Park YH, Pera P, Veith JM, Bernacki RJ.
Ojima I, et al. Among authors: takeuchi cs.
J Med Chem. 1997 Jan 31;40(3):267-78. doi: 10.1021/jm960563e.
J Med Chem. 1997.
PMID: 9022793
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Structural requirements of taxoids for nitric oxide and tumor necrosis factor production by murine macrophages.
Kirikae T, Ojima I, Kirikae F, Ma Z, Kuduk SD, Slater JC, Takeuchi CS, Bounaud PY, Nakano M.
Kirikae T, et al. Among authors: takeuchi cs.
Biochem Biophys Res Commun. 1996 Oct 3;227(1):227-35. doi: 10.1006/bbrc.1996.1494.
Biochem Biophys Res Commun. 1996.
PMID: 8858130
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