Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Moye AL, Dost AF, Ietswaart R, Sengupta S, Ya V, Aluya C, Fahey CG, Louie SM, Paschini M, Kim CF.
Moye AL, et al.
EMBO J. 2024 May 16. doi: 10.1038/s44318-024-00113-5. Online ahead of print.
EMBO J. 2024.
PMID: 38755258
The injury state in AT2(KRAS) cells of patients, mice, and organoids was distinguishable from AT2(WT) states via altered receptor expression, including co-expression of ITGA3 and SRC. ...
The injury state in AT2(KRAS) cells of patients, mice, and organoids was distinguishable from AT2(WT) states via altered receptor exp …