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A non-canonical mechanism of GPCR activation.
Powers AS, Khan A, Paggi JM, Latorraca NR, Souza S, Salvo JD, Lu J, Soisson SM, Johnston JM, Weinglass AB, Dror RO. Powers AS, et al. bioRxiv [Preprint]. 2023 Aug 15:2023.08.14.553154. doi: 10.1101/2023.08.14.553154. bioRxiv. 2023. PMID: 37645874 Free PMC article. Preprint.
Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Nat Chem Biol. 2023 Jul;19(7):805-814. doi: 10.1038/s41589-022-01247-5. Epub 2023 Feb 13. Nat Chem Biol. 2023. PMID: 36782010 Free PMC article.
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.
Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Dang Do AN, Porter FD, Ori A, Sabatini DM, Abu-Remaileh M. Laqtom NN, et al. Nature. 2022 Sep;609(7929):1005-1011. doi: 10.1038/s41586-022-05221-y. Epub 2022 Sep 21. Nature. 2022. PMID: 36131016 Free PMC article.
76 results