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Site-directed mutagenesis of amino acids 33-44 of the common alpha-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3',5'-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin.
Grossmann M, Szkudlinski MW, Dias JA, Xia H, Wong R, Puett D, Weintraub BD. Grossmann M, et al. Among authors: szkudlinski mw. Mol Endocrinol. 1996 Jun;10(6):769-79. doi: 10.1210/mend.10.6.8776737. Mol Endocrinol. 1996. PMID: 8776737
Recombinant thyrotropin containing a beta-subunit chimera with the human chorionic gonadotropin-beta carboxy-terminus is biologically active, with a prolonged plasma half-life: role of carbohydrate in bioactivity and metabolic clearance.
Joshi L, Murata Y, Wondisford FE, Szkudlinski MW, Desai R, Weintraub BD. Joshi L, et al. Among authors: szkudlinski mw. Endocrinology. 1995 Sep;136(9):3839-48. doi: 10.1210/endo.136.9.7544273. Endocrinology. 1995. PMID: 7544273
Substitution of the seat-belt region of the thyroid-stimulating hormone (TSH) beta-subunit with the corresponding regions of choriogonadotropin or follitropin confers luteotropic but not follitropic activity to chimeric TSH.
Grossmann M, Szkudlinski MW, Wong R, Dias JA, Ji TH, Weintraub BD. Grossmann M, et al. Among authors: szkudlinski mw. J Biol Chem. 1997 Jun 13;272(24):15532-40. doi: 10.1074/jbc.272.24.15532. J Biol Chem. 1997. PMID: 9182589 Free article.
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