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Mast cells infiltrate pancreatic islets in human type 1 diabetes.
Martino L, Masini M, Bugliani M, Marselli L, Suleiman M, Boggi U, Nogueira TC, Filipponi F, Occhipinti M, Campani D, Dotta F, Syed F, Eizirik DL, Marchetti P, De Tata V. Martino L, et al. Among authors: syed f. Diabetologia. 2015 Nov;58(11):2554-62. doi: 10.1007/s00125-015-3734-1. Epub 2015 Aug 15. Diabetologia. 2015. PMID: 26276263
Biomarkers of β-Cell Stress and Death in Type 1 Diabetes.
Mirmira RG, Sims EK, Syed F, Evans-Molina C. Mirmira RG, et al. Among authors: syed f. Curr Diab Rep. 2016 Oct;16(10):95. doi: 10.1007/s11892-016-0783-x. Curr Diab Rep. 2016. PMID: 27541297 Free PMC article. Review.
DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes.
Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Vistoli F, Filipponi F, De Simone P, Marselli L, De Tata V, Ahren B, Eizirik DL, Marchetti P. Bugliani M, et al. Among authors: syed f. Mol Cell Endocrinol. 2018 Sep 15;473:186-193. doi: 10.1016/j.mce.2018.01.019. Epub 2018 Feb 1. Mol Cell Endocrinol. 2018. PMID: 29409957
Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice.
Tersey SA, Levasseur EM, Syed F, Farb TB, Orr KS, Nelson JB, Shaw JL, Bokvist K, Mather KJ, Mirmira RG. Tersey SA, et al. Among authors: syed f. FASEB J. 2018 May 29;32(11):fj201800150RR. doi: 10.1096/fj.201800150RR. Online ahead of print. FASEB J. 2018. PMID: 29812970 Free PMC article.
In conclusion, early episodic beta-cell death may be a feature of cellular turnover correlated with changes in glycemia during beta-cell mass accrual in obesity, whereas beta-cell dedifferentiation may be a feature seen later in established disease.-Tersey, S. A., Levasseur, E. M …
In conclusion, early episodic beta-cell death may be a feature of cellular turnover correlated with changes in glycemia during beta-cell mas …
Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.
Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C. Sims EK, et al. Among authors: syed f. Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9. Transl Res. 2019. PMID: 31442418 Free PMC article.
451 results