Swayze EE - Search Results

1

Tau-targeting antisense oligonucleotide MAPT_Rx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial.

Mummery CJ, Börjesson-Hanson A, Blackburn DJ, Vijverberg EGB, De Deyn PP, Ducharme S, Jonsson M, Schneider A, Rinne JO, Ludolph AC, Bodenschatz R, Kordasiewicz H, Swayze EE, Fitzsimmons B, Mignon L, Moore KM, Yun C, Baumann T, Li D, Norris DA, Crean R, Graham DL, Huang E, Ratti E, Bennett CF, Junge C, Lane RM. Mummery CJ, et al. Among authors: swayze ee. Nat Med. 2023 Jun;29(6):1437-1447. doi: 10.1038/s41591-023-02326-3. Epub 2023 Apr 24. Nat Med. 2023. PMID: 37095250 Free PMC article. Clinical Trial.

2

Synthesis and biological activity of 5-fluorotubercidin.

Wang X, Seth PP, Ranken R, Swayze EE, Migawa MT. Wang X, et al. Among authors: swayze ee. Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):161-70. doi: 10.1081/ncn-120027825. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15043144

3

Synthesis, antiproliferative and antiviral activity of imidazo[4,5-d]isothiazole nucleosides as 5:5 fused analogs of nebularine and 6-methylpurine ribonucleoside.

Swayze EE, Drach JC, Wotring LL, Townsend LB. Swayze EE, et al. J Med Chem. 1997 Feb 28;40(5):771-84. doi: 10.1021/jm960605z. J Med Chem. 1997. PMID: 9057864

4

Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents.

Townsend LB, Drach JC, Wotring LL, Vittori S, Pudlo JS, Swayze EE, Gupta P, Maruyama T, Saxena N, Coleman LA, et al. Townsend LB, et al. Among authors: swayze ee. Farmaco. 1991 Jan;46(1 Suppl):113-39. Farmaco. 1991. PMID: 1649609 No abstract available.

5

Synthesis of 2'-substituted MMI linked nucleosidic dimers: an optimization study in search of high affinity oligonucleotides for use in antisense constructs.

Peoc'h D, Swayze EE, Bhat B, Sanghvi YS. Peoc'h D, et al. Among authors: swayze ee. Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):411-38. doi: 10.1081/ncn-120028337. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15043164

6

Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay.

Ding Y, Hofstadler SA, Swayze EE, Risen L, Griffey RH. Ding Y, et al. Among authors: swayze ee. Angew Chem Int Ed Engl. 2003 Jul 28;42(29):3409-12. doi: 10.1002/anie.200351354. Angew Chem Int Ed Engl. 2003. PMID: 12888972 No abstract available.

7

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Wancewicz EV, Witchell D, Swayze EE. Seth PP, et al. Among authors: swayze ee. J Med Chem. 2009 Jan 8;52(1):10-3. doi: 10.1021/jm801294h. J Med Chem. 2009. PMID: 19086780

8

Biaryl guanidine inhibitors of in vitro HCV-IRES activity.

Jefferson EA, Seth PP, Robinson DE, Winter DK, Miyaji A, Osgood SA, Swayze EE, Risen LM. Jefferson EA, et al. Among authors: swayze ee. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5139-43. doi: 10.1016/j.bmcl.2004.07.066. Bioorg Med Chem Lett. 2004. PMID: 15380215

9

Optimizing the antibacterial activity of a lead structure discovered by "SAR by MS" technology.

Jefferson EA, Seth PP, Robinson DE, Winter DK, Miyaji A, Risen LM, Osgood SA, Bertrand M, Swayze EE. Jefferson EA, et al. Among authors: swayze ee. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5257-61. doi: 10.1016/j.bmcl.2004.08.033. Bioorg Med Chem Lett. 2004. PMID: 15454207

10

Aryl urea analogs with broad-spectrum antibacterial activity.

Seth PP, Ranken R, Robinson DE, Osgood SA, Risen LM, Rodgers EL, Migawa MT, Jefferson EA, Swayze EE. Seth PP, et al. Among authors: swayze ee. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5569-72. doi: 10.1016/j.bmcl.2004.08.059. Bioorg Med Chem Lett. 2004. PMID: 15482926

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